|Cas No:||128-13-2||Ec No:||204-879-3|
|Name:||Ursodeoxycholic Acid/ UDCA||Synonyms:||Tauroursodiol;Urosodeoxycholic Acid;Ursodeoxycholic Acid(micronized);URSODEOXYCHOLIC ACID;URSODESOXYCHOLIC ACID;URSODIOL;URSODEOXYCHOLOC ACID;UDCA|
|Molecular Formula:||C24H40O4||Molecular Weight:||392.57|
|Melting Po 203-204int:||203-204 °C (lit.)||Density:||0.9985|
|Boiling Point:||437.26°C||Solubility:||Practically Insoluble|
cas no 128-13-2,
Ursodeoxycholic Acid api,
Ursodeoxycholic Acid powder
|Name||Ursodeoxycholic Acid/ UDCA|
|Synonyms||Tauroursodiol;Urosodeoxycholic Acid;Ursodeoxycholic acid(micronized);URSODIOL;|
|CAS Registry Number||128-13-2|
|Melting point||203-204 °C (lit.)|
Choleretic drugs are generally divided into two major categories: Choleretic agents and liquid-increase Choleretic agent. The former refers to the drug can promote the secretion of bile. The latter one refers only to those drugs which can increase capacity without increasing bile. The most commonly used Choleretic drugs is mainly cholic acid class-based such as sodium dehydroepiandrosterone acid, chenodeoxycholic acid and ursodeoxycholic acid and so on.
Ursodeoxycholic acid is a chemical agent of natural bile acid which is isolated from the bile of bear. It is the stereo-isomer of chenodeoxycholic acid. It has a similar litholysis effect, efficacy as chenodeoxycholic acid. However, it has a short course of treatment and a small dose. It is bound with taurine in the bile in vivo, and is a hydrophilic bile acids as well as a dissolving agent of cholesterol. It can reduce the secretion of cholesterol in the liver, lower the saturation content of cholesterol in bile, promote the secretion of bile acids, and increase the solubility of cholesterol in the bile so that cholesterol gallstones can be dissolved or prevented. Moreover, it can increase the secretion amount of bile, and have a choleretic effect by relaxing the bile duct mouth sphincter which smoothen the discharge of calculus. This product, however, cannot dissolve other types of gallstones. Ursodeoxycholic acid is useful in the treatment of cholesterol stones, hyperlipidemia, bile secretion disorders, primary biliary cirrhosis, chronic hepatitis, bile reflux gastritis and prevention of liver allograft rejection and reaction. The calculus-dissolving effect of this product is slightly weaker than the CDCA.
1. Gallstone-dissolving drugs. Mainly used for the treatment of inoperable cholesterol gallstones, it will have a cure rate especially in the case when gallbladder is basically normal, stones have a 15mm or lower diameters, X-ray penetrable, non-calcified and high-floating cholesterol stones. It also has some therapeutic effect against toxic hepatitis, cholecystitis, primary sclerosing cholangitis, and primary cholestatic cirrhosis. It can also improve the efficacy of α-interferon on treatment of chronic hepatitis C. It can also used to treat diarrhea, rare constipation, allergic reactions, itching, headache, dizziness, stomach pain, pancreatitis and bradycardia Patients of completely biliary obstruction or severe liver dysfunction and pregnant women should avoid using.
2. For the prevention and treatment of cholesterol gallstones.
3. Anionic detergents, for biochemical research.
|1||62-46-4||Alpha Lipoic Acid|
|12||128-13-2||Ursodeoxycholic Acid/ UDCA|