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|Other Name:||4 - Aminobenzoic Acid ( PABA )||CAS:||150-13-0|
|Use:||Sunscreen Agent||Standard:||USP EP|
|Appearance:||White Crystalline Powder||Trade Terms:||FOB CNF CIF DAP|
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P - aminobenzoic acid Active Pharmaceutical Intermediates for against fibrotic skin disorders
P- aminobenzoic acid ( PABA ) is a compound formed by the substitution of amino-substituted benzene of benzoic acid (4-bit).
Aminobenzoic acid is one of the components of folate which is essential for cell growth and division of body cells and is very high in yeast, liver, bran and malt.It is synthesized by a branch of shikimic acid. The first step reaction is that the branch acid reacts with ammonia to form the 4 - amino - 4 - deoxybranchic acid, catalyzed by the amino deoxygenation process. Then the 4 - amino - 4 - deoxidized branch acid removes a pyruvate, and aromatic is converted into aminobenzoic acid. The second step in the bacteria is catalyzed by the amino deoxygenation process, which is likely to have similar enzymes in plants, but has not been found.
|Molar mass||137.14 g·mol−1|
|Melting point||187 to 189 °C (369 to 372 °F; 460 to 462 K)|
|Boiling point||340 °C (644 °F; 613 K)|
Solubility in water
|1 g/170 mL (25 °C)
1 g/90 mL (90 °C)
PABA is an intermediate in the synthesis of folate by bacteria, plants, and fungi. Many bacteria, including those found in the human intestinal tract such as E.coli, generate PABA from chorismate by the combined action of the enzymes 4 - amino - 4 - deoxychorismate synthase and 4 - amino - 4 - deoxychorismate lyase.
Plants produce PABA in their chloroplasts, and store it as a glucose ester ( pABA-Glc ) in their tissues. Humans lack the enzymes to convert PABA to folate, so require folate from dietary sources such as green leafy vegetables. In humans, PABA is considered nonessential and, although it has been referred to historically as " vitamin Bx ", is no longer recognized as a vitamin, because most people have colon bacteria that generate PABA.
Sulfonamide drugs are structurally similar to PABA, and their antibacterial activity is due to their ability to interfere with the conversion of PABA to folate by the enzyme dihydropteroate synthetase. Thus, bacterial growth is limited through folate deficiency.
PABA is largely nontoxic; the median lethal dose of PABA in dogs ( oral ) is 2 g/kg. Allergic reactions to PABA can occur. It is formed in the metabolism of certain ester local anesthetics, and many allergic reactions to local anesthetics are the result of reactions to PABA.
|Characters||White or off - white crystalline powder.||White crystalline powder|
|Identification||IR should comply with the reference standard specturm. UV should comply with the reference standard specturm.||IR complies with the reference standard specturm. UV complies with the reference standard specturm.|
|Volatile diazoizable substances||Not more than 0.002%||Conforms|
|Loss on drying||Not more than 0.2%||0.12%|
|Residue on ignition||Not more than 0.1%||0.04%|
|Heavy metals||Not more than 0.002%||Conforms|