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CAS 50-27-1 Estriol Powder For Preventing Vaginal Atrophy , C18H24O3 Pharmaceutical Intermediates 

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CAS 50-27-1 Estriol Powder For Preventing Vaginal Atrophy , C18H24O3 Pharmaceutical Intermediates 

China CAS 50-27-1 Estriol Powder For Preventing Vaginal Atrophy , C18H24O3 Pharmaceutical Intermediates  supplier

Large Image :  CAS 50-27-1 Estriol Powder For Preventing Vaginal Atrophy , C18H24O3 Pharmaceutical Intermediates 

Product Details:

Place of Origin: China
Brand Name: PooChun
Certification: ISO9001 SGS HACCP
Model Number: 50-27-1

Payment & Shipping Terms:

Minimum Order Quantity: Negotiable
Price: Negotiable
Packaging Details: 1~10 kg / Al-Pt bag,10kg / 25kg fiber drum
Delivery Time: 1-3days after payment
Payment Terms: T/T, L/C, Western Union, MoneyGram
Supply Ability: 500 ton per Month
Detailed Product Description
CAS: 50-27-1 Use: Replacement Estrogen In Breast Cancer Survivors
Shipping: DHL TNT FedEx HKEMS UPS Trade Terms: FOB CNF CIF DAP DDU
Appearance: Powder MF: C18H24O3

Estriol Pharmaceutical Raw Materials Prevents Vaginal Atrophy and Urinary Tract Infections

 

Biochemistry

 

1.    Biosynthesis

In women who are not pregnant estriol is produced in only very small quantities, and circulating levels are in fact barely detectable. Unlike estradiol and estrone, estriol is not synthesized in or secreted from the ovaries, and is instead derived mainly if not exclusively from 16α - hydroxylation of estradiol and estrone by cytochrome P450 enzymes ( e.g., CYP3A4 ) mainly in the liver. Estriol is cleared from the circulation rapidly in non - pregnant women, and so circulating levels are very low, but concentrations of estriol in the urine are relatively high.

Although circulating levels of estriol are very low outside of pregnancy, parous women have been found to have levels of estriol that are to some degree higher than those of nulliparous women.

2.    In pregnant women

Estriol is produced in quantities that are notable only during pregnancy. Levels of estriol increase 1,000-fold during pregnancy, whereas levels of estradiol and estrone increase 100-fold, and estriol accounts for 90% of the estrogens in the urine of pregnant women. At term, the daily production of estriol by the placenta is 35 to 45 mg, and levels in the maternal circulation are 8 to 13 ng/dL.

 

 

Use in screening

 

Estriol can be measured in maternal blood or urine and can be used as a marker of fetal health and well - being. If levels of unconjugated estriol ( uE3 or free estriol ) are abnormally low in a pregnant woman, this may indicate chromosomal or congenital anomalies like Down syndrome or Edward's syndrome. It is included as part of the triple test and quadruple test for antenatal screening for fetal anomalies.

Because many pathological conditions in a pregnant woman can cause deviations in estriol levels, these screenings are often seen as less definitive of fetal - placental health than a nonstress test. Conditions which can create false positives and false negatives in estriol testing for fetal distress include preeclampsia, anemia, and impaired kidney function.

 

 

Product Catalogs

 

Fermentation ( Starting Materials & Intermediates ) Chemical Synthesis ( Intermediates )
4-androstenedione ( 4 - AD ) Dehydroepiandrosterone ( DHEA )
1,4-androstadienedione ( ADD ) Epiandrosterone
9a - hydroxy - 4 - androstenedione ( 9- OH -4- AD ) Androstanolone
21 - hydroxy - 20 - methylpregn - 4 - ene - 3 - one ( Bisnoralcohol, BA ) Mestanolone
Sitolactone ( δ- Lactone ) 17a-hydroxyprogesterone
11 a, 17 a - dihydroxyprogesterone 19-nor-4-androstenedione
11 a - hydroxy Canrenone Methyldienedione ( Estra -4,9- diene -3,17-dione )
3b,7a,15a - trihydroxyandrost - 5 - ene - 17- one Tertraene Acetate ( 3TR )
  Tertraene 21 - Methyl ( 5ST )
Chemical Synthesis ( API ) Canrenone
Spironolactone Estrone
Stanozolol  
Progesterone Chemical Synthesis ( API )
Estradiol & esters Testosterone & esters
Estriol Nandrolone & esters
Altrenogest Boldenone & esters
  Trenbolone & esters
  Metenolone & esters

 

 

CAS 50-27-1 Estriol Powder For Preventing Vaginal Atrophy , C18H24O3 Pharmaceutical Intermediates 

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