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Valsartan Medicine Raw Material For Posterior Myocardial Infarction / Primary Hypertension

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Valsartan Medicine Raw Material For Posterior Myocardial Infarction / Primary Hypertension

China Valsartan Medicine Raw Material For Posterior Myocardial Infarction / Primary Hypertension supplier

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Product Details:

Place of Origin: China
Brand Name: PooChun
Certification: ISO9001 SGS GMP
Model Number: 137862-53-4

Payment & Shipping Terms:

Minimum Order Quantity: Negotiable
Price: Negotiable
Packaging Details: 1 / kg double layer plastic bags inside and aluminum foil bag outside, 25 / kg paper drum and two plastic bags inside.
Delivery Time: 1-3days after payment
Payment Terms: T/T, L/C
Supply Ability: 2000 kg per Month
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Detailed Product Description
Other Name: Valsartane CAS: 137862-53-4
Type: Angiotensin II Receptor Antagonist Use: Antihypertensive
Appearance: White Powder MF: C24H29N5O3
Trade Terms: FOB CNF CIF DAP DDU Shipping: DHL TNT FedEx HKEMS UPS Sea Air
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Valsartan Medicine Raw Material for Treat Posterior Myocardial Infarction primary hypertension

 

 

Description

 

Valsartan is an angiotensin II receptor antagonist antihypertensive drugs, the drug is a make angiotensin Ⅱ type 1 ( AT1 ) receptor blockade, angiotensin Ⅱ plasma levels, stimulate non - sealing AT2 receptors, against the effect of AT1 receptor at the same time, so as to achieve to dilate blood vessels the effect of lowering blood pressure.

 

In the United States, valsartan is a drug used to treat hypertension, congestive heart failure and post - myocardial infarction.

 

Switzerland ciba - fine base company research and development production of the generation of valsartan in 1995 and 1996, respectively, to obtain a patent in the United States and Europe, and in July 1996 for the first time to market in Germany, then gradually in Europe, America, Japan. Valsartan has the characteristics of stable hypotension effect and small toxicity.

 

 

Medical uses

 

Valsartan is used to treat high blood pressure, congestive heart failure, and to reduce death for people with left ventricular dysfunction after having had a heart attack.

 

In people with type II diabetes and high blood pressure or albumin in the urine, valsartan is used to slow the worsening and the development end-stage renal disease.

 

 

Mechanism of action

 

Valsartan blocks the actions of angiotensin II, which include constricting blood vessels and activating aldosterone, to reduce blood pressure. The drug binds to angiotensin type I receptors ( AT1 ), working as an antagonist. This mechanism of action is different than the ACE inhibitor drugs, which block the conversion of angiotensin I to angiotensin II.

 

Since valsartan acts at the receptor, it can provide more complete angiotensin II antagonism since angiotensin II is generated by other enzymes as well as ACE. Also, valsartan does not affect the metabolism of bradykinin like ACE inhibitors do.

 

 

Specification

 

Item Specification Result
Appearance White to almost white powder White powder
Identification Infrared absorption: The IR spectrum is consistent with that obtained with the reference Conforms
The retention time of the major peak in the chromatogram of the Assay preparation corresponds to that in the chromatogram of the Standard preparation, as obtained in the Assay. Conforms
Absorbance NMT 0.02% Conforms
Water NMT 2.0% 0.51%
Residue on ignition NMT 0.1% 0.07%
Heavy metals NMT 0.001% Complies
Related compounds ( HPLC ) Compound A NMT 1.0% 0.59%
Compound B NMT 0.2% 0.04%
Compound C NMT 0.1% 0.05%
Any other individual impurity NMT 0.1% ( excluding compound A ) 0.07%
Total impurities NMT 0.3% ( excluding compound A ) 0.16%
Residual solvents ( GC ) Ethyl acetate NMT 5000ppm 305ppm
Dichloromethane NMT 600ppm Undetected
Methanol NMT 3000ppm Undetected
N, N - Dimethylformamide NMT 880PPM Undetected
Assay ( HPLC ) 98.0%~102.0% 99.65%

 

 

Production

 

Valsartan Medicine Raw Material For Posterior Myocardial Infarction / Primary Hypertension

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Shanghai Poochun Industry Co.,Ltd

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