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Synthetic Steroids Pharmaceutical Raw Materials Oxandrolone for treating osteoporosis muscle - building
Oxandrolone possesses many functions that are beneficial but it is in its ability to reduce Sex Hormone Binding Globulin ( SHBG ) glucocorticoid hormones and increases in nitrogen retention that make it so valuable. An increase in nitrogen retention creates a more apt anabolic environment where as a reduced one leads to catabolism.
The decrease in SHBG promotes higher levels of free testosterone and also frees any and other anabolic steroidal hormones from being bound. Lower SHBG can result in more of a punch from the steroids you’re using. We’re then left with the reduction of glucocorticoids, muscle wasting hormones. These hormones promote fat gain and muscle loss; they literally do the opposite of what you’re after.
Oxandrolone is widely used due to its exceptionally small level of androgenicity [ citation needed ] accompanied by moderate anabolic effect. Although oxandrolone is a 17- alpha alkyloid, its liver toxicity is very small as well. Studies have showed that a daily dose of 20 mg oxandrolone used in the course of 12 weeks had only a negligible impact on the increase of liver enzymes. As a DHT derivative, oxandrolone does not aromatize ( convert to estrogen, which causes gynecomastia or male breast tissue ).
It also does not significantly influence the body's normal testosterone production ( HPTA axis ) at low dosages ( 20 mg ). When dosages are high, the human body reacts by reducing the production of LH ( luteinizing hormone ), thinking endogenous testosterone production is too high; this in turn eliminates further stimulation of Leydig cells in the testicles, causing testicular atrophy ( shrinking ). Oxandrolone used in a dose of 20 mg / day suppressed endogenous testosterone by 67% after 12 weeks of therapy.
Many bodybuilders and athletes use oxandrolone for its muscle - building properties. It is much less androgenic than anabolic, so women and those seeking less intense steroid regimens use it particularly often. Many also value oxandrolone's low hepatotoxicity relative to most other orally active steroids. The infamous "duchess" cocktail administered to Russian athletes at the Sochi Winter Olympics consisted of Oxandrolone, Methenolone and Trenbolone.
Like other anabolic steroids, oxandrolone may worsen hypercalcemia by increasing osteolytic bone resorption. When taken by pregnant women, oxandrolone may have unintended effects such as masculinization on the fetus.
|Fermentation ( Starting Materials & Intermediates )||Chemical Synthesis ( Intermediates )|
|4-androstenedione ( 4 - AD )||Dehydroepiandrosterone ( DHEA )|
|1,4-androstadienedione ( ADD )||Epiandrosterone|
|9a - hydroxy - 4 - androstenedione ( 9- OH -4- AD )||Androstanolone|
|21 - hydroxy - 20 - methylpregn - 4 - ene - 3 - one ( Bisnoralcohol, BA )||Mestanolone|
|Sitolactone ( δ- Lactone )||17a-hydroxyprogesterone|
|11 a, 17 a - dihydroxyprogesterone||19-nor-4-androstenedione|
|11 a - hydroxy Canrenone||Methyldienedione ( Estra -4,9- diene -3,17-dione )|
|3b,7a,15a - trihydroxyandrost - 5 - ene - 17- one||Tertraene Acetate ( 3TR )|
|Tertraene 21 - Methyl ( 5ST )|
|Chemical Synthesis ( API )||Canrenone|
|Progesterone||Chemical Synthesis ( API )|
|Estradiol & esters||Testosterone & esters|
|Estriol||Nandrolone & esters|
|Altrenogest||Boldenone & esters|
|Trenbolone & esters|
|Metenolone & esters|