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|Type:||Estrogen Steroid Powder||CAS:||57-83-0|
|Use:||Female Sex Hormone||MF:||C21H30O2|
|Trade Terms:||FOB CNF CIF DAP DDU||Shipping:||DHL TNT FedEx HKEMS UPS|
medicine raw material
Neuromodulators Progesterone Pharmaceutical Raw Materials for hormone replacement therapy Sex drive
Progesterone is a hormone released by luteal cells in the ovaries which contains 21 Carbon Atoms. Progesterone is also a crucial metabolic intermediate in the production of other endogenous steroids. There are two crystal forms of progesterone, that are type-α and type-β, the two types have similar physiological activity. Type-α is precipitated from dilute ethanol as orthorhombic white prismatic crystal, while type-β is orthorhombic white needle crystal, they are both insoluble in water, but soluble in ethanol, ethyl ether, chloroform, acetone, dioxane and concentrated sulfuric acid.
Progesterone and its neurosteroid active metabolite allopregnanolone appear to be importantly involved in sex drive in females.
Dr. Diana Fleischman, of the University of Portsmouth, and colleagues examined the relationship between progesterone and sexual attitudes. Their research was published in the Archives of Sexual Behavior. They found that women who have higher levels of progesterone are more likely to be open to the idea of engaging in sexual behaviour with other women. This pattern is particularly dramatic in men who have high levels of progesterone.
Progesterone, like pregnenolone and dehydroepiandrosterone ( DHEA ), belongs to an important group of endogenous steroids called neurosteroids. It can be metabolized within all parts of the central nervous system.
Neurosteroids are neuromodulators, and are neuroprotective, neurogenic, and regulate neurotransmission and myelination. The effects of progesterone as a neurosteroid are mediated predominantly through its interactions with non-nuclear PRs, namely the mPRs and PGRMC1, as well as certain other receptors, such as the σ1 and nACh receptors.
Since most progesterone in males is created during testicular production of testosterone, and most in females by the ovaries, the shutting down ( whether by natural or chemical means ), or removal, of those inevitably causes a considerable reduction in progesterone levels. Previous concentration upon the role of progestogens in female reproduction, when progesterone was simply considered a " female hormone ", obscured the significance of progesterone elsewhere in both sexes.
The tendency for progesterone to have a regulatory effect, the presence of progesterone receptors in many types of body tissue, and the pattern of deterioration ( or tumor formation ) in many of those increasing in later years when progesterone levels have dropped, is prompting widespread research into the potential value of maintaining progesterone levels in both males and females
|Fermentation ( Starting Materials & Intermediates )||Chemical Synthesis ( Intermediates )|
|4-androstenedione ( 4 - AD )||Dehydroepiandrosterone ( DHEA )|
|1,4-androstadienedione ( ADD )||Epiandrosterone|
|9a - hydroxy - 4 - androstenedione ( 9- OH -4- AD )||Androstanolone|
|21 - hydroxy - 20 - methylpregn - 4 - ene - 3 - one ( Bisnoralcohol, BA )||Mestanolone|
|Sitolactone ( δ- Lactone )||17a-hydroxyprogesterone|
|11 a, 17 a - dihydroxyprogesterone||19-nor-4-androstenedione|
|11 a - hydroxy Canrenone||Methyldienedione ( Estra -4,9- diene -3,17-dione )|
|3b,7a,15a - trihydroxyandrost - 5 - ene - 17- one||Tertraene Acetate ( 3TR )|
|Tertraene 21 - Methyl ( 5ST )|
|Chemical Synthesis ( API )||Canrenone|
|Progesterone||Chemical Synthesis ( API )|
|Estradiol & esters||Testosterone & esters|
|Estriol||Nandrolone & esters|
|Altrenogest||Boldenone & esters|
|Trenbolone & esters|
|Metenolone & esters|