Payment & Shipping Terms:
|Trade Terms:||FOB CNF CIF DAP DDU||Shipping:||DHL TNT FedEx HKEMS UPS|
medicine raw material
Female Sex Hormone Pharmaceutical Raw Materials Progesterone for Breast Cancer Treatment
Progesterone is an endogenous steroid and progestogen sex hormone involved in the menstrual cycle, pregnancy, and embryogenesis of humans and other species. It belongs to a group of steroid hormones called the progestogens, and is the major progestogen in the body. Progesterone is also a crucial metabolic intermediate in the production of other endogenous steroids, including the sex hormones and the corticosteroids, and plays an important role in brain function as a neurosteroid.
Progesterone has a number of physiological effects that are amplified in the presence of estrogens. Estrogens through estrogen receptors ( ERs ) induce or upregulate the expression of the PR. One example of this is in breast tissue, where estrogens allow progesterone to mediate lobuloalveolar development.
Elevated levels of progesterone potently reduce the sodium - retaining activity of aldosterone, resulting in natriuresis and a reduction in extracellular fluid volume. Progesterone withdrawal, on the other hand, is associated with a temporary increase in sodium retention ( reduced natriuresis, with an increase in extracellular fluid volume ) due to the compensatory increase in aldosterone production, which combats the blockade of the mineralocorticoid receptor by the previously elevated level of progesterone.
Progesterone has key effects via non-genomic signalling on human sperm as they migrate through the female tract before fertilization occurs, though the receptor ( s ) as yet remain unidentified. Detailed characterisation of the events occurring in sperm in response to progesterone has elucidated certain events including intracellular calcium transients and maintained changes, slow calcium oscillations, now thought to possibly regulate motility. It is produced by the ovaries. Interestingly, progesterone has also been shown to demonstrate effects on octopus spermatozoa.
|Fermentation ( Starting Materials & Intermediates )||Chemical Synthesis ( Intermediates )|
|4-androstenedione ( 4 - AD )||Dehydroepiandrosterone ( DHEA )|
|1,4-androstadienedione ( ADD )||Epiandrosterone|
|9a - hydroxy - 4 - androstenedione ( 9- OH -4- AD )||Androstanolone|
|21 - hydroxy - 20 - methylpregn - 4 - ene - 3 - one ( Bisnoralcohol, BA )||Mestanolone|
|Sitolactone ( δ- Lactone )||17a-hydroxyprogesterone|
|11 a, 17 a - dihydroxyprogesterone||19-nor-4-androstenedione|
|11 a - hydroxy Canrenone||Methyldienedione ( Estra -4,9- diene -3,17-dione )|
|3b,7a,15a - trihydroxyandrost - 5 - ene - 17- one||Tertraene Acetate ( 3TR )|
|Tertraene 21 - Methyl ( 5ST )|
|Chemical Synthesis ( API )||Canrenone|
|Progesterone||Chemical Synthesis ( API )|
|Estradiol & esters||Testosterone & esters|
|Estriol||Nandrolone & esters|
|Altrenogest||Boldenone & esters|
|Trenbolone & esters|
|Metenolone & esters|