Payment & Shipping Terms:
|Shipping:||DHL TNT FedEx HKEMS UPS||Payment Terms:||TT L/C Western Union Moneygram|
medicine raw material
Estriol Pharmaceutical Raw Materials Protects Against Breast Treating Multiple Sclerosis
Estriol is an estrogen, specifically an agonist of the estrogen receptors ERα and ERβ. It is a far less potent estrogen than is estradiol, and as such is a relatively weak estrogen. According to one in vitro study, the relative binding affinity ( RBA ) of estriol for the human ERα and ERβ was 11.3% and 17.6% of that estradiol, respectively, and the relative transactivational capacity of estrone at the ERα and ERβ was 10.6% and 16.6% of that of estradiol, respectively. According to another in vitro study however, the RBA of estriol for the ERα and ERβ were 14% and 21% of those of estradiol, respectively, suggesting that unlike estradiol and estrone, estriol may have preferential affinity for ERβ.
Although estriol is an efficacious agonist of the ERs, it is reported to have mixed agonist – antagonist ( partial agonist ) activity at the ER; on its own, it is weakly estrogenic, but in the presence estradiol, it is antiestrogenic. Relative to estradiol, the esstrogenic potency of estriol and estrone have been reported to be 80- and 12- fold lower than that of estradiol, respectively. It is notable that unlike estriol, estrone can be metabolized into estradiol, and most of its potency in vivo is in fact actually due to conversion into estradiol.
In addition to acting as an agonist of the nuclear ERs, estriol also acts as an antagonist of the GPER at high concentrations, a membrane estrogen receptor where, conversely, estradiol acts as an agonist. Estradiol increases breast cancer cell growth via activation of the GPER ( in addition to the ER ), and estriol has been found to inhibit estradiol - induced proliferation of triple-negative breast cancer cells through blockade of the GPER.
Estriol is poorly bound to sex hormone - binding globulin ( SHBG ), with much lower binding affinity for this protein, relative to estradiol, and hence a greater fraction available for biological activity.
|Algestone acetophenide||Medroxyprogesterone acetate|
|Melengestrol acetate||Mometasone furoate|
|Betamethasone acetate||Beclomethasone dipropionate|
|Betamethasone Dipropionate||Betamethasone 17-valerate|