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CAS 50-27-1 Estriol powder for Protecting Breast / Treating Multiple Sclerosis

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CAS 50-27-1 Estriol powder for Protecting Breast / Treating Multiple Sclerosis

China CAS 50-27-1 Estriol powder for Protecting Breast / Treating Multiple Sclerosis supplier

Large Image :  CAS 50-27-1 Estriol powder for Protecting Breast / Treating Multiple Sclerosis

Product Details:

Place of Origin: China
Brand Name: PooChun
Certification: ISO9001 SGS HACCP
Model Number: 50-27-1

Payment & Shipping Terms:

Minimum Order Quantity: Negotiable
Price: Negotiable
Packaging Details: 1~10 kg / Al-Pt bag,10kg / 25kg fiber drum
Delivery Time: 1-3days after payment
Payment Terms: T/T, L/C
Supply Ability: 500 ton per Month
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Detailed Product Description
CAS: 50-27-1 Use: Menopausal Symptoms
Shipping: DHL TNT FedEx HKEMS UPS Payment Terms: TT L/C Western Union Moneygram
Appearance: Powder Sample: Yes
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steroid hormones

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medicine raw material

Estriol Pharmaceutical Raw Materials Protects Against Breast Treating Multiple Sclerosis

 

 

Biological activity

 

Estriol is an estrogen, specifically an agonist of the estrogen receptors ERα and ERβ. It is a far less potent estrogen than is estradiol, and as such is a relatively weak estrogen. According to one in vitro study, the relative binding affinity  ( RBA ) of estriol for the human ERα and ERβ was 11.3% and 17.6% of that estradiol, respectively, and the relative transactivational capacity of estrone at the ERα and ERβ was 10.6% and 16.6% of that of estradiol, respectively. According to another in vitro study however, the RBA of estriol for the ERα and ERβ were 14% and 21% of those of estradiol, respectively, suggesting that unlike estradiol and estrone, estriol may have preferential affinity for ERβ.

 

Although estriol is an efficacious agonist of the ERs, it is reported to have mixed agonist – antagonist ( partial agonist ) activity at the ER; on its own, it is weakly estrogenic, but in the presence estradiol, it is antiestrogenic. Relative to estradiol, the esstrogenic potency of estriol and estrone have been reported to be 80- and 12- fold lower than that of estradiol, respectively. It is notable that unlike estriol, estrone can be metabolized into estradiol, and most of its potency in vivo is in fact actually due to conversion into estradiol.

 

In addition to acting as an agonist of the nuclear ERs, estriol also acts as an antagonist of the GPER at high concentrations, a membrane estrogen receptor where, conversely, estradiol acts as an agonist. Estradiol increases breast cancer cell growth via activation of the GPER ( in addition to the ER ), and estriol has been found to inhibit estradiol - induced proliferation of triple-negative breast cancer cells through blockade of the GPER.

 

 

Distribution

 

Estriol is poorly bound to sex hormone - binding globulin ( SHBG ), with much lower binding affinity for this protein, relative to estradiol, and hence a greater fraction available for biological activity.

 

 

Product Catalogs

 

Estradiol Estrone
Estradiol valerate Estriol
Estradiol benzoate Nylestriol
Estradiol cypionate Diethylstilbestrol
Estradiol enantate HEXESTROL
Ethynyl estradiol Progesterone
Algestone acetophenide Medroxyprogesterone acetate
Ethisterone Norethindrone
19-Norethindrone acetate Mifepristone
Norethisterone Enanthate Methyldienedione
Ethynodiol diacetate Eplerenone
Pregnenolone acetate Levonorgestrel
Lynestrenol Allylestrenol
Chlormadinone acetate Dienogestrel
Cyproterone acetate Drospirenone
Megestrol acetate Pregnenolone
Melengestrol acetate Mometasone furoate
Betamethasone acetate Beclomethasone dipropionate
Betamethasone Dipropionate Betamethasone 17-valerate

 

CAS 50-27-1 Estriol powder for Protecting Breast / Treating Multiple Sclerosis

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