Home ProductsPharma Raw Material

C24H32O4S Hormones Aldactone Spironolactone For Male Sexual Dysfunction Treatment

Certification
Good quality Pharma Raw Material for sales
Good quality Pharma Raw Material for sales
I'm Online Chat Now

C24H32O4S Hormones Aldactone Spironolactone For Male Sexual Dysfunction Treatment

China C24H32O4S Hormones Aldactone Spironolactone For Male Sexual Dysfunction Treatment supplier

Large Image :  C24H32O4S Hormones Aldactone Spironolactone For Male Sexual Dysfunction Treatment

Product Details:

Place of Origin: China
Brand Name: PooChun
Certification: ISO9001 SGS HACCP
Model Number: 52-01-7

Payment & Shipping Terms:

Minimum Order Quantity: Negotiable
Price: Negotiable
Packaging Details: 1~10 kg / Al-Pt bag,10kg / 25kg fiber drum
Delivery Time: 1-3days after payment
Payment Terms: T/T, L/C
Supply Ability: 500 ton per Month
Contact Now
Detailed Product Description
Name: Spironolactone MF: C24H32O4S
CAS: 52-01-7 Trade Terms: FOB CNF CIF DAP DDU
Purity: 99% Shipping: DHL TNT FedEx HKEMS UPS
High Light:

steroid hormones

,

medicine raw material

Hormones Aldactone Spironolactone Pharmaceutical Raw Materials For Male Sexual Dysfunction Treatment

 

 

Description

 

Spironolactone is a potent and direct antagonist of the AR, blocking androgens like testosterone from binding to and activating the receptor. The AR antagonism of spironolactone mostly underlies its antiandrogen activity and is responsible for its therapeutic benefits in the treatment of androgen - dependent conditions like acne, hirsutism, and pattern hair loss and its usefulness in hormone therapy for transgender women. In addition, the AR antagonism of spironolactone is involved in its feminizing side effects like gynecomastia in men.

 

Spironolactone, similarly to other steroidal antiandrogens such as cyproterone acetate, is actually not a pure, or silent, antagonist of the AR, but rather is a weak partial agonist with the capacity for both antagonistic and agonistic effects. However, in the presence of sufficiently high levels of potent full agonists like testosterone and DHT  ( the cases in which spironolactone is usually used even with regards to the " lower " relative levels present in females ), spironolactone will behave more similarly to a pure antagonist.

 

 

Applications

 

Androgens like testosterone and DHT play a critical role in the pathogenesis of a number of dermatological conditions including acne, seborrhea, hirsutism ( excessive facial/body hair growth in women ), and pattern hair loss ( androgenic alopecia ).

 

In demonstration of this, women with complete androgen insensitivity syndrome ( CAIS ) do not produce sebum or develop acne and have little to no body, pubic, or axillary hair. Moreover, men with congenital 5α-reductase type II deficiency 5α-reductase being an enzyme that greatly potentiates the androgenic effects of testosterone in the skin, have little to no acne, scanty facial hair, reduced body hair, and reportedly no incidence of male pattern hair loss.

 

Conversely, hyperandrogenism in women, for instance due to polycystic ovary syndrome ( PCOS ) or congenital adrenal hyperplasia ( CAH ), is commonly associated with acne and hirsutism as well as virilization ( masculinization ) in general. In accordance with the preceding, antiandrogens are highly effective in the treatment of the aforementioned androgen-dependent skin and hair conditions

 

By acting as an antiandrogen, as androgens can suppress both estrogen production and signaling ( e.g., in the breasts ).

 

Inhibition of the conversion of estradiol to estrone, resulting in an increase in the ratio of circulating estradiol to estrone. Estradiol is far more potent than estrone as an estrogen, which is comparatively almost inactive.

 

Enhancement of the rate of peripheral conversion of testosterone into estradiol, thus decreasing the ratio of circulating testosterone to estradiol.

 

 

 

Specification

 

Test Items Specification Test Results
Description White or off - white crystalline powder Off - white crystalline powder
Specific rotation -56°~-60° -58.2°
Identification IR Matches with working standard Complies
HPLC
Solubility Freely soluble in chloroform and in alcohol; Very slightly soluble in water Conform
Heavy metals ≤10ppm <10ppm
Water ≤0.3% 0.22%
Residue on ignition ≤0.1% 0.05%
Relative material Maximum impurities ≤0.5% 0.36%
Total impurities ≤1.0% 0.52%
Assay 98.5~101.0% 99.68%
Conclusion The specification conform with USP.

 

 

 

Packaging & Delivery

 

We have professional team for package and shipment. Special way to ship 100 grams to 100kg powders at one time to your country. Fast and discreet shipment could be arranged for customs pass Guaranteed.

 

 

C24H32O4S Hormones Aldactone Spironolactone For Male Sexual Dysfunction Treatment

Contact Details
Shanghai Poochun Industry Co.,Ltd

Send your inquiry directly to us (0 / 3000)