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Androgen 53-43-0 Pharmaceutical Grade Dhea Dehydroepiandrosterone Increasing Endogenous Production

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Androgen 53-43-0 Pharmaceutical Grade Dhea Dehydroepiandrosterone Increasing Endogenous Production

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Product Details:

Place of Origin: China
Brand Name: PooChun
Certification: ISO9001 SGS HACCP
Model Number: 53-43-0

Payment & Shipping Terms:

Minimum Order Quantity: Negotiable
Price: Negotiable
Packaging Details: 1~10 kg / Al-Pt bag,10kg / 25kg fiber drum
Delivery Time: 1-3days after payment
Payment Terms: T/T, L/C
Supply Ability: 100 ton per Month
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Detailed Product Description
CAS: 53-43-0 Appearance: White Powder
Type: Androgen Grade: Pharmaceutical Grade
MF: C19H28O2 Trade Terms: FOB CNF CIF DAP DDU
Shipping: DHL TNT FedEx HKEMS UPS Payment Terms: T/T, Western Union, Moneygram
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Androgen Pharmaceutical Raw Materials Dehydroepiandrosterone Increasing endogenous production

 

 

Description

 

Dehydroepiandrosterone ( DHEA ), also known as androstenolone, is an endogenous steroid hormone. It is one of the most abundant circulating steroids in humans, in whom it is produced in the adrenal glands, the gonads, and the brain, where it functions as a metabolic intermediate in the biosynthesis of the androgen and estrogen sex steroids. However, DHEA also has a variety of potential biological effects in its own right, binding to an array of nuclear and cell surface receptors, and acting as a neurosteroid and neurotrophin.

 

 

 

Biological function

1. As an androgen

DHEA and other adrenal androgens such as androstenedione, although relatively weak androgens, are responsible for the androgenic effects of adrenarche, such as early pubic and axillary hair growth, adult - type body odor, increased oiliness of hair and skin, and mild acne. Women with complete androgen insensitivity syndrome ( CAIS ), who have a non-functional androgen receptor ( AR ) and are immune to the androgenic effects of DHEA and other androgens, have absent or only sparse/scanty pubic and axillary hair and body hair in general, demonstrating the role of DHEA, testosterone, and other androgens in body hair development at both adrenarche and pubarche.

2. As a neurosteroid

As a neurosteroid and neurotrophin, DHEA has important effects in the central nervous system.

 

 

Metabolism

 

DHEA is transformed into DHEA - S by sulfation at the C3β position via the sulfotransferase enzymes SULT2A1 and to a lesser extent SULT1E1. This occurs naturally in the adrenal cortex and during first - pass metabolism in the liver and intestines when exogenous DHEA is administered orally. Levels of DHEA - S in circulation are approximately 250 to 300 times those of DHEA. DHEA-S in turn can be converted back into DHEA in peripheral tissues via steroid sulfatase ( STS ).

 

The terminal half-life of DHEA is short at only 15 to 30 minutes. In contrast, the terminal half-life of DHEA - S is far longer, at 7 to 10 hours. As DHEA - S can be converted back into DHEA, it serves as a circulating reservoir for DHEA, thereby extending the duration of DHEA.

Metabolites of DHEA include DHEA-S, 7α-hydroxy - DHEA, 7β - hydroxy - DHEA, 7- keto - DHEA, 7α - hydroxyepiandrosterone, and 7β - hydroxyepiandrosterone, as well as androstenediol and androstenedione.

 

 

Product Catalogs

 

Fermentation ( Starting Materials & Intermediates ) Chemical Synthesis ( Intermediates )
4-androstenedione ( 4 - AD ) Dehydroepiandrosterone ( DHEA )
1,4-androstadienedione ( ADD ) Epiandrosterone
9a - hydroxy - 4 - androstenedione ( 9- OH -4- AD ) Androstanolone
21 - hydroxy - 20 - methylpregn - 4 - ene - 3 - one ( Bisnoralcohol, BA ) Mestanolone
Sitolactone ( δ- Lactone ) 17a-hydroxyprogesterone
11 a, 17 a - dihydroxyprogesterone 19-nor-4-androstenedione
11 a - hydroxy Canrenone Methyldienedione ( Estra -4,9- diene -3,17-dione )
3b,7a,15a - trihydroxyandrost - 5 - ene - 17- one Tertraene Acetate ( 3TR )
  Tertraene 21 - Methyl ( 5ST )
Chemical Synthesis ( API ) Canrenone
Spironolactone Estrone
Stanozolol  
Progesterone Chemical Synthesis ( API )
Estradiol & esters Testosterone & esters
Estriol Nandrolone & esters
Altrenogest Boldenone & esters
  Trenbolone & esters
  Metenolone & esters

 

 

Androgen 53-43-0 Pharmaceutical Grade Dhea Dehydroepiandrosterone Increasing Endogenous Production

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