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Spironolactone, marketed beneath the brand name Aldactone amongst others, is a medication which is primarily accustomed to treat fluid build - up because of heart failure, liver scarring, or kidney disease. Additionally it is used in the treating high blood pressure, low blood potassium that will not improve with supplementation, early-onset puberty, and acne and excessive growth of hair in women. It is also used for hormone therapy in transgender women. Spironolactone is taken orally.
Spironolactone commonly referred to simply as spiro, and marketed primarily within the brand name Aldactone for most countries, is often a synthetic, steroidal antimineralocorticoid and antiandrogen that also has some weak progestogen properties, and also some indirect estrogen and glucocorticoid effects.
It really is used primarily being a diuretic and antihypertensive, but can also be employed for the goal of reducing elevated or unwanted androgen activity within the body. It acts predominantly being an antagonist with the mineralocorticoid and androgen receptors, plus relation to its antimineralocorticoid effects, is assigned to a class of drugs known as potassium-sparing diuretics.
Spironolactone can be used primarily to help remedy heart failure, edematous conditions like nephrotic syndrome or ascites in patients with liver disease, essential hypertension, hypokalemia, secondary hyperaldosteronism, and Conn's syndrome .
Spironolactone is utilized primarily to help remedy heart failure, edematous conditions such as nephrotic syndrome or ascites in people with liver disease, essential hypertension, hypokalemia, secondary hyperaldosteronism ( including occurs with hepatic cirrhosis ), and Conn's syndrome ( primary hyperaldosteronism ). Alone, spironolactone is only a weak diuretic since it primarily targets the distal nephron ( collecting tubule ), where only small quantities of sodium are reabsorbed, but it can be combined with other diuretics to boost efficacy.
|Test Items||Specification||Test Results|
|Description||White or off - white crystalline powder||Off - white crystalline powder|
|Identification||IR||Matches with working standard||Complies|
|Solubility||Freely soluble in chloroform and in alcohol; Very slightly soluble in water||Conform|
|Residue on ignition||≤0.1%||0.05%|
|Relative material||Maximum impurities ≤0.5%||0.36%|
|Total impurities ≤1.0%||0.52%|
|Conclusion||The specification conform with USP29|
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