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|CAS:||70-18-8||Apperance:||White Crystalline Powder|
|Use:||Increase Skin Elasticity, Shrink Pores, Lighten Pigment, The Body Has An Excellent Whitening Effect.||Shipping:||DHL TNT FedEx EMS UPS By Sea By Air|
|MF:||C10H17N3O6S||Trade Terms:||FOB CNF CIF DAP DDU|
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Glutathione Cosmetic Raw Materials for increase skin elasticity and shrink pores
Glutathione ( GSH ) is an important antioxidant in plants, animals, fungi, and some bacteria and archaea. Glutathione is capable of preventing damage to important cellular components caused by reactive oxygen species such as free radicals, peroxides, lipid peroxides, and heavy metals. It is a tripeptide with a gamma peptide linkage between the carboxyl group of the glutamate side chain and the amine group of cysteine, and the carboxyl group of cysteine is attached by normal peptide linkage to a glycine.
Thiol groups are reducing agents, existing at a concentration around 5 mM in animal cells. Glutathione reduces disulfide bonds formed within cytoplasmic proteins to cysteines by serving as an electron donor. In the process, glutathione is converted to its oxidized form, glutathione disulfide ( GSSG ), also called L - ( – ) - glutathione.
Once oxidized, glutathione can be reduced back by glutathione reductase, using NADPH as an electron donor. The ratio of reduced glutathione to oxidized glutathione within cells is often used as a measure of cellular oxidative stress.
The content of glutathione in must, the first raw form of wine, determines the browning, or caramelizing effect, during the production of white wine by trapping the caffeoyltartaric acid quinones generated by enzymic oxidation as grape reaction product. Its concentration in wine can be determined by UPLC - MRM mass spectrometry.
Glutathione plays an important role in preventing oxidative damage to the skin. In addition to its many recognized biological functions, glutathione has also been associated with skin lightening ability. The role of glutathione as a skin whitener was discovered as a side effect of large doses of glutathione. Glutathione utilizes different mechanisms to exert its action as a skin whitening agent at various levels of melanogenesis. It inhibits melanin synthesis by means of stopping the neurotransmitter precursor L - DOPA's ability to interact with tyrosinase in the process of melanin production. Glutathione inhibits the actual production as well as agglutination of melanin by interrupting the function of L - DOPA. Another study found that glutathione inhibits melanin formation by direct inactivation of the enzyme tyrosinase by binding and chelating copper within the enzyme's active site. Glutathione's antioxidant property allows it to inhibit melanin synthesis by quenching of free radicals and peroxides that contribute to tyrosinase activation and melanin formation. Its antioxidant property also protects the skin from UV radiation and other environmental as well as internal stressors that generate free radicals that cause skin damage and hyperpigmentation. In most mammals, melanin formation consists of eumelanin (brown - black pigment) and pheomelanin ( yellow - red pigment ) as either mixtures or co - polymers. Increase in glutathione level may induce the pigment cell to produce pheomelanin instead of eumelanin pigments. A research by Te - Sheng Chang found lowest levels of reduced glutathione to be associated with eumelanin type pigmentation, whereas the highest ones were associated with the pheomelanin. As a result, it is reasonable to assume that depletion of glutathione would result in eumelanin formation. Prota observed that decreased glutathione concentration led to the conversion of L - Dopaquinone to Dopachrome, increasing the formation of brown - black pigment ( eumelanin ).
|Description||White crystalline powder||White crystalline powder|
|Melting point||About 185℃||185.0℃|
|Identification IR||Similar with the Reference Spectrum||Complies|
|Optical Rotation||-15.5°~ -17.5°||-16.1°|
|Clearity and color of solution||Clear and colourless||Clear and colourless|
|Loss on Drying||≤0.5%||0.19%|
|Residue on Ignition||≤0.1%||0.03%|
|Assay||98.0％ ~ 101.0%||99.1%|
|Conclusion:Comply with the standard of JP XV.|