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white crystalline powder

Diovan Angiotensin Receptor Blocker GMP Valsartan White Crystalline Powder CAS 137862-53-4

  • Diovan Angiotensin Receptor Blocker GMP Valsartan White Crystalline Powder CAS 137862-53-4
Product Details:

Diovan Medicine Raw Material GMP Valsartan Treat Congestive Heart Failure CAS 137862-53-4

 

 

Description

 

Valsartan belong to non peptide, orally active angiotensin Ⅱ ( AT ) receptor antagonist. It is highly selective for Ⅰ type ( AT1 ) receptor, can be competitive antagonism to without any excitement. It can also be mediated by inhibition of AT1 receptor adrenal cells release aldehyde sterol, but for potassium caused by the release of valsartan no inhibition, it also suggests that valsartan for AT1 receptor selectivity.

 

The experiments of various types of hypertensive animal models showed that valsartan had a good hypotensive effect, which had no significant effect on cardiac systolic function and heart rate. Animals with normal blood pressure do not have a blood pressure lowering effect. The uptake was rapid and bioavailability was 23 %. The binding rate of plasma protein was 94% ~ 97%. About 70% of the excrement is excreted, and 30% of the renal excretion is in the original form. T1 over 2 beta is about 9 hours. It is not affected by the combination of food and food.

 

The blood pressure began to decline after 2 hours after taking a patient with high blood pressure, and the maximum blood pressure effect was reached between 4 and 6 hours. The hypotensive effect lasts for 24 hours. The maximal effect of blood pressure was decreased by 2 ~ 4 weeks after continuous use. It can be used in combination with hydrochlorothiazide, and the blood pressure can be enhanced.

 

 

Uses

 

Blood pressure medicine. Valsartan for angiotensin Ⅱ ( Ang Ⅱ) receptor antagonist, can selectively block Ang Ⅱ combined with AT1 receptor ( its specificity of AT1 receptor of antagonism effect about 20000 times greater than AT2 ), thus inhibiting vascular contraction and the release of aldosterone, antihypertensive effect.

 

 

Contraindications

 

The packaging for valsartan includes a warning stating the drug should not be used with the renin inhibitor aliskiren in people with diabetes mellitus. It also states the drug should not be used in people with kidney disease.

 

Valsartan falls in FDA pregnancy category D and includes a black box warning for fetal toxicity. Discontinuation of these agents is recommended immediately after detection of pregnancy and an alternative medication should be started. The US labeling makes no recommendation regarding continuation or discontinuation of valsartan for breast-feeding mothers. The Canadian labeling does not recommend use by nursing women.

 

Specification

 

 

Item Specification Result
Appearance White to almost white powder White powder
Identification Infrared absorption: The IR spectrum is consistent with that obtained with the reference Conforms
The retention time of the major peak in the chromatogram of the Assay preparation corresponds to that in the chromatogram of the Standard preparation, as obtained in the Assay. Conforms
Absorbance NMT 0.02% Conforms
Water NMT 2.0% 0.51%
Residue on ignition NMT 0.1% 0.07%
Heavy metals NMT 0.001% Complies
Related compounds ( HPLC ) Compound A NMT 1.0% 0.59%
Compound B NMT 0.2% 0.04%
Compound C NMT 0.1% 0.05%
Any other individual impurity NMT 0.1% ( excluding compound A ) 0.07%
Total impurities NMT 0.3% ( excluding compound A ) 0.16%
Residual solvents ( GC ) Ethyl acetate NMT 5000ppm 305ppm
Dichloromethane NMT 600ppm Undetected
Methanol NMT 3000ppm Undetected
N, N - Dimethylformamide NMT 880PPM Undetected
Assay ( HPLC ) 98.0%~102.0% 99.65%

 

85-43-8 Tetrahydrophthalic Anhydride , White Crystalline Powder THPA

  • 85-43-8 Tetrahydrophthalic Anhydride , White Crystalline Powder THPA
Product Details:

Tetrahydrophthalic anhydride Medicine Raw Material THPA for insecticides and sulfide regulator

 


Description

 

Tetrahydrophthalic anhydride by maleic anhydride and 1, 3 - butadiene in the presence of catalyst preparation and the addition reaction of as intermediates in organic synthesis, are commonly used to produce alkyd resins and unsaturated polyester resin, paint, also used as the curing agent of epoxy resin, and also used in pesticide, sulfide regulator, plasticizer, surface active agent and so on.

 

 

Other name

 

1,2,3,6-TETRAHYDROPHTHALIC ANHYDRIDE; 3A,4,7,7A-TETRAHYDRO-2-BENZOFURAN-1,3-DIONE; 4-CYCLOHEXENE-1,2-DICARBOXYLIC ANHYDRIDE; CIS-1,2,3,6-TETRAHYDROPHTHALIC ANHYDRIDE; CIS-4-CYCLOHEXEN-1,2-DIMETHANOIC ANHYDRIDE; CIS-4-CYCLOHEXENE-1,2-DICARBOXYLIC ANHYDRIDE; CIS-4-TETRAHYDROPHTHALIC ANHYDRIDE; CIS-DELTA4-TETRAHYDROPHTHALIC ANHYDRIDE; CIS-THPA; TETRAHYDROPHTHALIC ANHYDRIDE; THPA; 1,3-isobenzofurandion,3a,4,7,7a-tetrahydro-,cis-; 3-Isobenzofurandione,3a,4,7,7a-tetrahydro-,cis-1; 4,7,7a-tetrahydro-3-isobenzofurandioncis-3a; cis-3a,4,7,7a-Tetrahydro-1,3-isobenzofurandione.

 

 

Usage

 

As an organic intermediate,THPA is usually used in the production of alkyd and unsaturated polyester resins,coatings and the curing agent for the epoxy resins,and also used in insecticides,sulfide regulator, plasticizers, surfactant, alkyd resin modifier,pesticides and the raw materials of pharmaceuticals.

As raw materials for the production of unsaturated polyester, THPA mainly improved the air-drying performance of resins.The performance is more obvious especially in the production of high-grade resin putty and air - drying coatings.

 

Specification

 

Appearance white flakes
Purity ≥99.0%
Chromaticity ≤80# (Pt-Co)
Melting Point 100.0±2.0oC

 

Packing

 

25kg/bag,500kg/bag

 

 

Storage

 

This product shall be airtight, out of the sun, moisture-proof and away from het .The storage period is one year.

 

Product name
Tetrahydrophthalic Anhydride(THPA)
  CAS NO: 85-43-8
  Molecular formula
Chemical formula: C8H8O3
Structural formula:  
Molecular weight: 152.16
  Technical indicators
White flaky solid,≧99.0%
  Use

As an organic intermediate,THPA is usually used in the production of alkyd and unsaturated polyester resins,coatings and the curing agent for the epoxy resins,and also used in insecticides,sulfide regulator, plasticizers, surfactant, alkyd resin modifier,pesticides and the raw materials of pharmaceuticals.

As raw materials for the production of unsaturated polyester, THPA mainly improved the air-drying performance of resins.The performance is more obvious especially in the production of high-grade resin putty and air-drying coatings.

  Packing
25kg/bag,500kg/bag
  Storage
This product shall be airtight, out of the sun, moisture-proof and away from het .The storage period is one year.

PDE5 Inhibitor White Crystalline Powder Tadalafil 171596-29-5 For Male Erectile Dysfunction

  • PDE5 Inhibitor White Crystalline Powder Tadalafil 171596-29-5 For Male Erectile Dysfunction
Product Details:

PDE5 Inhibitor Medicine Raw Material Tadalafil For Male Erectile Dysfunction 171596-29-5

 

 

Description

 

Tadalafil ( INN ) is a PDE5 inhibitor marketed in pill form for treating erectile dysfunction ( ED ) under the name Cialis / siˈælᵻs / see - AL - iss, and under the name Adcirca / ædˈsɜːrkə / ad - SUR - kə for the treatment of pulmonary arterial hypertension. In October 2011 the U.S. Food and Drug Administration ( FDA ) approved Cialis for treating the signs and symptoms of benign prostatic hyperplasia ( BPH ) as well as a combination of BPH and erectile dysfunction when the conditions coincide.

 

It initially was developed by the biotechnology company ICOS, and then again developed and marketed worldwide by Lilly ICOS, LLC, the joint venture of ICOS Corporation and Eli Lilly and Company. Cialis tablets, in 2.5 mg, 5 mg, 10 mg, and 20 mg doses, are yellow, film - coated, and almond - shaped. The approved dose for pulmonary arterial hypertension is 40 mg ( two 20 mg tablets ) once daily.

 

Drug interactions

 

Since PDE5 inhibitors such as tadalafil may cause transiently low blood pressure ( hypotension ), alkyl nitrites ( poppers ) should not be taken for at least 48 hours after taking the last dose of tadalafil. Using poppers ( such as the sex drug amyl nitrite ) within this timeframe may increase the risk of life - threatening hypotension.

 

Since people who have taken tadalafil within the past 48 hours cannot take organic nitrates to relieve angina ( such as glyceryl trinitrate spray ), these patients should seek immediate medical attention if they experience anginal chest pain. In the event of a medical emergency, paramedics and medical personnel should be notified of any recent doses of tadalafil.

 

Tadalafil is metabolized predominantly by the hepatic CYP3A4 enzyme system. The presence of other drugs which induce this system can shorten tadalafil half - life and reduce serum levels, and hence efficacy, of the drug.

 

Specification

 

Test Items Specification Test Results
Appearance White powder Conforms
Test method High pressure liquid chromatography(HPLC) Conforms
Melting Point 300℃~303℃ 301.5℃-302.6℃
Loss on drying ≤0.5% 0.24%
Heavy metals(Pb) ≤20ppm 7.5ppm
Residue on ignition ≤0.1% 0.08%
Relative substance ≤1.0% 0.145%
Assay (on dried basis) ≥98.5% 99.53%
Conclusion The product conform to USP 32
Product name Tadalafil
Other name cialis; chinacialis
CAS register number 171596-29-5
EINECS ---
Molecular formula C22H19N3O4
Molecular weight 389.341
Molecular structure Cialis Male Enhancer Tadalafil Citrate Raw Sex Powder 171596-29-5
Assay 99%
Appearance White powder
Package 1kg/aluminium foil bag or as required
Usage can be used as pharmaceutical material

Valsartan White Crystalline Powder For Posterior Myocardial Infarction

  • Valsartan White Crystalline Powder For Posterior Myocardial Infarction
Product Details:

Valsartan Medicine Raw Material for Treat Posterior Myocardial Infarction primary hypertension

 

 

Description

 

Valsartan is an angiotensin II receptor antagonist antihypertensive drugs, the drug is a make angiotensin Ⅱ type 1 ( AT1 ) receptor blockade, angiotensin Ⅱ plasma levels, stimulate non - sealing AT2 receptors, against the effect of AT1 receptor at the same time, so as to achieve to dilate blood vessels the effect of lowering blood pressure.

 

In the United States, valsartan is a drug used to treat hypertension, congestive heart failure and post - myocardial infarction.

 

Switzerland ciba - fine base company research and development production of the generation of valsartan in 1995 and 1996, respectively, to obtain a patent in the United States and Europe, and in July 1996 for the first time to market in Germany, then gradually in Europe, America, Japan. Valsartan has the characteristics of stable hypotension effect and small toxicity.

 

 

Medical uses

 

Valsartan is used to treat high blood pressure, congestive heart failure, and to reduce death for people with left ventricular dysfunction after having had a heart attack.

 

In people with type II diabetes and high blood pressure or albumin in the urine, valsartan is used to slow the worsening and the development end-stage renal disease.

 

 

Mechanism of action

 

Valsartan blocks the actions of angiotensin II, which include constricting blood vessels and activating aldosterone, to reduce blood pressure. The drug binds to angiotensin type I receptors ( AT1 ), working as an antagonist. This mechanism of action is different than the ACE inhibitor drugs, which block the conversion of angiotensin I to angiotensin II.

 

Since valsartan acts at the receptor, it can provide more complete angiotensin II antagonism since angiotensin II is generated by other enzymes as well as ACE. Also, valsartan does not affect the metabolism of bradykinin like ACE inhibitors do.

Specification

 

Item Specification Result
Appearance White to almost white powder White powder
Identification Infrared absorption: The IR spectrum is consistent with that obtained with the reference Conforms
The retention time of the major peak in the chromatogram of the Assay preparation corresponds to that in the chromatogram of the Standard preparation, as obtained in the Assay. Conforms
Absorbance NMT 0.02% Conforms
Water NMT 2.0% 0.51%
Residue on ignition NMT 0.1% 0.07%
Heavy metals NMT 0.001% Complies
Related compounds ( HPLC ) Compound A NMT 1.0% 0.59%
Compound B NMT 0.2% 0.04%
Compound C NMT 0.1% 0.05%
Any other individual impurity NMT 0.1% ( excluding compound A ) 0.07%
Total impurities NMT 0.3% ( excluding compound A ) 0.16%
Residual solvents ( GC ) Ethyl acetate NMT 5000ppm 305ppm
Dichloromethane NMT 600ppm Undetected
Methanol NMT 3000ppm Undetected
N, N - Dimethylformamide NMT 880PPM Undetected
Assay ( HPLC ) 98.0%~102.0% 99.65%

White Crystalline Powder 4, 4 ' - Propane - 2, 2 - Diyl Dicyclohexanol

  • White Crystalline Powder 4, 4 ' - Propane - 2, 2 - Diyl Dicyclohexanol
Product Details:

4, 4 ' - ( Propane - 2, 2 - diyl ) dicyclohexanol Medicine Raw Material for polycarbonate and polyacrylic acid resin

 


Description

 

HBPA is usually used in the production of epoxy resin, polycarbonate, polyacrylic acid resin and unsaturated resin, etc. It has a thermal stability, chemical stability , weather resistance, excellent electric properties, low viscosity, excellent processing technology, etc. As a type of weather resistance epoxy resin, epoxy resin of HBPA solves the limitations on the application of common epoxy resin of bisphenol A such as poor weather resistance, easy aging and weathering in the outdoors.

 

Used in the synthesis of drugs, dyes, photopolymrs and other photosensitive materials.

Name: 4, 4 ' - ( Propane - 2, 2 - diyl ) dicyclohexanol ( HBPA )

CAS NO: 80-04-6

MW: 240.38

Molecular Formula: C15H28O2

Appearance: white flaky solid

 

Packing

 

20kg/bag

 

 

Storage

 

This product shall be away from fire, moisture and sunlight.

Usage

 

HBPA is usually used in the production of epoxy resin ,polycarbonate, polyacrylic acid resin and unsaturated resin, etc. It has a thermal stability, chemical stability , weather resistance, excellent electric properties, low viscosity, excellent processing technology, etc. As a type of weather resistance epoxy resin, epoxy resin of HBPA solves the limitations on the application of common epoxy resin of bisphenol A such as poor weather resistance, easy aging and weathering in the outdoors.
4,4'-(Propane-2,2-diyl)dicyclohexanol (HBPA)

 

  Product name
4,4'-(Propane-2,2-diyl)dicyclohexanol (HBPA)
  CAS NO: 80-04-6
 
  Molecular formula
Chemical formula: C15H28O2
Structural formula:
Molecular weight: 240.38
 
  Technical indicators
Items Indcator
Appearance white flaky solid
Hazen(30%in methanol) ≤30
hydroxyl value,(mg KOH/g) ≥435
Content ≥95.0%
Water content ≤0.5
 
  Use
HBPA is usually used in the production of epoxy resin ,polycarbonate, polyacrylic acid resin and unsaturated resin, etc. It has a thermal stability, chemical stability , weather resistance, excellent electric properties, low viscosity, excellent processing technology, etc. As a type of weather resistance epoxy resin, epoxy resin of HBPA solves the limitations on the application of common epoxy resin of bisphenol A such as poor weather resistance, easy aging and weathering in the outdoors.
 
  Packing
20kg/bag
 
  Storage
This product shall be away from fire, moisture and sunlight.

Phenyl Succinic Anhydride White Crystalline Powder 1131-15-3 For Reagents Analysis

  • Phenyl Succinic Anhydride White Crystalline Powder 1131-15-3 For Reagents Analysis
Product Details:

Phenylsuccinic Anhydride Medicine Raw Material as pharmaceutical intermediates and analysis of reagents

 


Description

 

Mainly used in pharmaceutical intermediates, also used as the analysis of reagents.

Name: Phenylsuccinic Anhydride

CAS NO: 1131-15-3

MW: 176.17

Molecular Formula: C10H8O3

 

Usage

 

Phenylsuccinic Anhydride

 

  Product name
Phenylsuccinic Anhydride
  CAS NO: 1131-15-3
 
  Molecular formula
Chemical formula: C10H8O3
Structural formula:
Molecular weight: 176.17
 
  Technical indicators
 
 
  Use
Mainly used in pharmaceutical intermediates, also used as the analysis of reagents.
 
  Packing
25kg per barrel.
 
  Storage
Avoid contact with the oxide, acid, alkali, air and moisture. Be away from fire,one year.

Chloromethyl Triethoxysilane White Crystalline Powder For Coupling Agent CAS 15267-95-5

  • Chloromethyl Triethoxysilane White Crystalline Powder For Coupling Agent CAS 15267-95-5
Product Details:

Chloromethyltriethoxysilane Medicine Raw Material for coupling agent CAS 15267-95-5


Specification

Chemical Name: Chloromethyltriethoxysilane
Appearance: Colorless clear liquid.
CAS NO.: 15267-95-5
Purity: ≥ 97%
Formula: C7H17ClO3Si
Molecular Structure

Molecular Weight: 212.75
Boiling Point: 175oC
Density (ρ20) g/cm3: 1.022
Refractive Index (n25D): 1.4065


Applications

Used as freezing agent of silicon sulfide rubber in normal temperature, and as intermediate of silane coupling agent,etc.

Used as a coupling agent to improve adhesion of organic resins to inorganic surfaces.

Used as an intermediate for other functional organosilanes.
 

Product Name CAS No.
Acyloxy silane
3-Methacryloxypropyltriethoxysilane 21142-29-0
3-Methacryloylpropyltrimethoxysilane 2530-85-0
3-Methacryloxypropyltris(trimethylsiloxy)silane 17096-07-0
3-Methacryloxypropyltris(trimethylsiloxy)silane 65100-04-1
3-Methacryloxypropylmethyldimethoxysilane 14513-34-9
Mercapto silane
3-Mercaptopropyltrimethoxysilane 4420-74-0
3-Mercaptopropyltrimethoxysilane 14814-09-6
3-Mercaptopropylmethyldimethoxysilane 31001-77-1
3-Mercaptopropylmethyldiethoxysilane N/A
Phenyl silane
Diphenyldimethoxysilane 6843-66-9
N-phenyl-3-aminopropyltrimethoxysilane 3068-76-6
Phenyltriethoxysilane 780-69-8
Phenyltrimethoxysilane 2996-92-1
Phenyltrichlorosilane 98-13-5
Methylphenyldiethoxysilane 775-56-4
Methylphenyldichlorosilane 149-74-6
Methylphenyldimethoxysilane 3027-21-2
Octaphenylcyclotetrasiloxane 546-56-5
Fluoro silane
1H,1H,2H,2H-Perfluorodecyltrimethoxysilane 83048-65-1
1H,1H,2H,2H-Perfluorodecyltriethoxysilane 101947-16-4
1H,1H,2H,2H-Perfluorooctyltrimethoxysilane 85857-16-5
1H,1H,2H,2H-Perfluorooctyltriethoxysilane 51851-37-7
(3,3,3-Trifluoropropyl)trimethoxysilane 429-60-7
(3,3,3-Trifluoropropyl)methyldimethoxysilane 358-67-8
1,3,5-Tris(3,3,3-trifluoropropyl)methylcyclotrisiloxane 2374-14-3
Crosslinking agent
Vinyltriacetoxysilane 4130-8-9
Methyltriethoxysilane 2031-67-6
Methyltrimethoxysilane 1185-55-3
Crosslinking agent for silane cross-linked polyethylene N/A
1,1,3,3-Tetramethyl-2-[3-(trimethoxysilyl)propyl]guanidine 69709-01-9

Silane coupling agent product catalogue

Product Name CAS No.
Vinyl silane
Vinyltrichlorosilane 75-94-5
Vinyltriethoxysilane 78-08-0
Vinyltrimethoxysilane 2768-2-7
Vinyltris(2-methoxyethoxy)silane 1067-53-4
Vinyltriisopropoxysilane 18023-33-1
Vinyltris(methylethylketoximino)silane 2224-33-1
Methylvinyldimethoxysilane 16753-62-1
Methylvinyldiethoxysilane 5507-44-8
Methylvinyldichlorosilane 124-70-9
Vinyltriisopropenoxysilane 15332-99-7
Vinyltris(tert-Butylperoxy)silane 15188-09-7
Basic silane
Dimethyldichlorosilane 75-78-5
Bis(3-trimethoxysilylpropyl)amine 82985-35-1
Diethylenetriaminopropyltrimethoxysilane 35141-30-1
Dimethyldimethoxysilane 1112-39-6
Dimethyldiethoxysilane 78-62-6
Methyldichlorosilane 75-54-7
Methyltrichlorosilane 75-79-6
Chloromethyltriethoxysilane 15267-95-5
Tetraethyl orthosilicate 1978-10-4
Propyltrimethoxysilane 1067-25-0
Propyltriethoxysilane 2550-2-9
3-Chloropropyltriethoxysilane 5089-70-3
3-Chloropropyltrimethoxysilane 2530-87-2
Trimethoxysilane 2487-90-3
Chloromethyltrichlorosilane 1558-25-4
Amino silane
N-(2-aminoethyl)-3-aminopropyltrimethoxysilane 1760-24-3
N-(2-aminoethyl)-3-aminopropylmethyldimethoxysilane 3069-29-2
3-Aminopropylmethyldimethoxysilane 3663-44-3
3-Aminopropylmethyldiethoxysilane 3179-76-8
3-Aminopropyltrimethoxysilane 13822-56-5
3-Aminopropyltriethoxysilane 919-30-2
Diethylaminomethyltriethoxysilane 15180-47-9
N-(3-(Trimethoxysilyl)propyl)butylamine 31024-56-3
Epoxy silane
3-(2,3-Epoxypropoxypropyl)methyldiethoxysilane 2897-60-1
3-(2,3-Epoxypropoxypropyl)triethoxysilane 2602-34-8
2-(3,4-Epoxycyclohexyl)ethyltrimethoxysilane 3388-4-3
3-(2,3-Epoxypropoxypropyl)trimethoxysilane 2530-83-8
2-(3,4-Epoxycyclohexyl)ethyltriethoxysilane 10217-34-2
3-(2,3-Epoxypropoxypropyl)methyldimethoxysilane 65799-47-5
1,1,3,3-tetramethyl-1,3-bis[3-(oxiranylmethoxy)propyl]-Disiloxane 126-80-7
Alkyl silane
Dodecyltrichlorosilane 4484-72-4
Dodecyltriethoxysilane 18536-91-9
Dodecyltrimethoxysilane 3069-21-4
Octyltrimethoxysilane 3069-40-7
Octyltriethoxysilane 2943-75-1
Hexadecyltrimethoxysilane 16415-12-6

 

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