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CAS 50-27-1 Pharmaceutical Grade Steroids Estriol Powder For Preventing Vaginal Atrophy

  • CAS 50-27-1 Pharmaceutical Grade Steroids Estriol Powder For Preventing Vaginal Atrophy
Product Details:

Estriol Pharmaceutical Raw Materials Prevents Vaginal Atrophy and Urinary Tract Infections

 

Biochemistry

 

1. Biosynthesis

In women who are not pregnant estriol is produced in only very small quantities, and circulating levels are in fact barely detectable. Unlike estradiol and estrone, estriol is not synthesized in or secreted from the ovaries, and is instead derived mainly if not exclusively from 16α - hydroxylation of estradiol and estrone by cytochrome P450 enzymes ( e.g., CYP3A4 ) mainly in the liver. Estriol is cleared from the circulation rapidly in non - pregnant women, and so circulating levels are very low, but concentrations of estriol in the urine are relatively high.

Although circulating levels of estriol are very low outside of pregnancy, parous women have been found to have levels of estriol that are to some degree higher than those of nulliparous women.

2. In pregnant women

Estriol is produced in quantities that are notable only during pregnancy. Levels of estriol increase 1,000-fold during pregnancy, whereas levels of estradiol and estrone increase 100-fold, and estriol accounts for 90% of the estrogens in the urine of pregnant women. At term, the daily production of estriol by the placenta is 35 to 45 mg, and levels in the maternal circulation are 8 to 13 ng/dL.

 

 

Use in screening

 

Estriol can be measured in maternal blood or urine and can be used as a marker of fetal health and well - being. If levels of unconjugated estriol ( uE3 or free estriol ) are abnormally low in a pregnant woman, this may indicate chromosomal or congenital anomalies like Down syndrome or Edward's syndrome. It is included as part of the triple test and quadruple test for antenatal screening for fetal anomalies.

Because many pathological conditions in a pregnant woman can cause deviations in estriol levels, these screenings are often seen as less definitive of fetal - placental health than a nonstress test. Conditions which can create false positives and false negatives in estriol testing for fetal distress include preeclampsia, anemia, and impaired kidney function.

Product Catalogs

 

Fermentation ( Starting Materials & Intermediates ) Chemical Synthesis ( Intermediates )
4-androstenedione ( 4 - AD ) Dehydroepiandrosterone ( DHEA )
1,4-androstadienedione ( ADD ) Epiandrosterone
9a - hydroxy - 4 - androstenedione ( 9- OH -4- AD ) Androstanolone
21 - hydroxy - 20 - methylpregn - 4 - ene - 3 - one ( Bisnoralcohol, BA ) Mestanolone
Sitolactone ( δ- Lactone ) 17a-hydroxyprogesterone
11 a, 17 a - dihydroxyprogesterone 19-nor-4-androstenedione
11 a - hydroxy Canrenone Methyldienedione ( Estra -4,9- diene -3,17-dione )
3b,7a,15a - trihydroxyandrost - 5 - ene - 17- one Tertraene Acetate ( 3TR )
  Tertraene 21 - Methyl ( 5ST )
Chemical Synthesis ( API ) Canrenone
Spironolactone Estrone
Stanozolol  
Progesterone Chemical Synthesis ( API )
Estradiol & esters Testosterone & esters
Estriol Nandrolone & esters
Altrenogest Boldenone & esters
  Trenbolone & esters
  Metenolone & esters

Ultraviolet Light Absorber Pharmaceutical Grade Steroids Benzocaine CAS 94-09-7

  • Ultraviolet Light Absorber Pharmaceutical Grade Steroids Benzocaine CAS 94-09-7
Product Details:

As Ultraviolet Light Absorber Pharmaceutical Raw Materials Benzocaine CAS 94-09-7

 

 

Standard

 

USP 39 , EP 8.5

 

Description

 

Benzocaine is a local anesthetic commonly used as a topical pain reliever or in cough drops. It is the active ingredient in many over - the - counter anesthetic ointments such as products for oral ulcers. It is also combined with antipyrine to form A/B otic drops to relieve ear pain and remove earwax.

 

Benzocaine is one of the compouns usedto produceOussoImitation, Orthocaine, and Procaine. At the same time, it is used as a local anesthetic in medicine, and has and analgesicandantipruritic effect.

 

It ismainly used for wounds, ulcers, mucosal surfaces, hemorrhoids narcotic pain, and itch. Benzocaine can also be used in its ointment form for relieving pain and lubrication fornasopharyngeal catheters, endoscopes, and other scopes.

 

 

Use

 

Benzocaine is indicated to treat a variety of pain - related conditions, also used as a key ingredient in numerous pharmaceuticals:

1. Local anesthesia of oral and pharyngeal mucous membranes ( sore throat, cold sores, canker sores, toothache, sore gums, denture irritation )

2. Surgical or procedural local anesthesia.

 

3. Some glycerol - based ear medications for use in removing excess wax as well as relieving ear conditions such as otitis media and swimmers ear.

 

4.Some previous diet products such as Ayds.

 

5.Some condoms designed to prevent premature ejaculation. Benzocaine largely inhibits sensitivity on the penis, and can allow for an erection to be maintained longer ( in a continuous act ) by delaying ejaculation. Conversely, an erection will also fade faster if stimulus is interrupted.

 

6.Benzocaine mucoadhesive patches have been used in reducing orthodontic pain.

 

7.Benzocaine was used in synthesis of Leteprinim.

Specification

 

Items Tested Specification Result
Characters A white, crystalline powder or colorless crystals. A white crystal.
Identification IR should comply with the Reference Standard spectrum.
UV should comply with the Reference Standard spectrum.
An orange-red precipitate is performed.
IR complies with the Reference standard spectrum.
UV complies with the Reference standard spectrum.
An orange-red precipitate is performed.
Melting range 88 ~ 92 degree 89.8-90.2 degree
Loss on Drying Not more than 1.0% 0.22%
Readily carbonizable Substances The resolution has no more color than Matching Fluid A. Conform
Residue on ignition Not more than 0.1% 0.02%
Heavy metals Not more than 0.001% Conform
Chloride Conform Conform
Assay ( HPLC ) 98.0%-102.0% 99.96%
Ordinary Impurities ≤1% Conform
Reaction Conform Conform

 

94-09-7 Pharmaceutical Grade Steroids Surgical Benzocaine Powder For Surface Anaesthetic

  • 94-09-7 Pharmaceutical Grade Steroids Surgical Benzocaine Powder For Surface Anaesthetic
  • 94-09-7 Pharmaceutical Grade Steroids Surgical Benzocaine Powder For Surface Anaesthetic
Product Details:

Benzocaine Pharmaceutical Raw Materials for Surface Anaesthetic, Surgical or Procedural Local Anesthesia

 

 

 

Description

 

Benzocaine is a surface anaesthetic with liposolubility. Compared with several other local anesthetics such as lidocaine, tetracaine, etc., its anaestheticeffect is smaller. Owing to the role it plays in mucosal, patientsfeel less discomfort from its treatment. It is a more liposoluble drug, it combines easilywith the lipid layer of the mucosa or skin, but it does not easily go through the human body to produce toxins.

 

Benzocaine temporarily relieves pain and itching skin in the wounds of mild burns, sunburn, trauma, and insect bites. Its external earpreparations can beused to reduce the pain and itching of acute congestive, concentrated otitis, or swimmers’ ear. It is also effective to toothache, sore throat, oral ulcers, hemorrhoids, anal fissure, and vulva Sao. As a male genital desensitizer, it slowsejaculation.

 

 

Use

 

Benzocaine is indicated to treat a variety of pain - related conditions.
Benzocaine may be used for:
Local anesthesia of oral and pharyngeal mucous membranes ( sore throat, cold sores, canker sores, toothache, sore gums, denture irritation )
Otic Pain ( earache )
Surgical or procedural local anesthesia
Benzocaine is used as a key ingredient in numerous pharmaceuticals, Benzocaine largely inhibits sensitivity on the penis, and can allow for an erection to be maintained longer ( in a continuous act ) by delaying ejaculation. Conversely, an erection will also fade faster if stimulus is interrupted.
Benzocaine mucoadhesive patches have been used in reducing orthodontic pain.
In Poland it is included, together with menthol and zinc oxide, in the liquid powder ( not to be confused with the liquid face powder ) used mainly after mosquito stings.
Benzocaine is commonly found, particularly in Britain, as an impurity in street . Whilst giving a numbing effect similar to on users' gums it does not actually produce the effects . But in terms of an orally based saliva drug test benzocaine can and has been mistaken for a false positive.

Specification

 

Items Tested Specification Result
Characters A white, crystalline powder or colorless crystals. A white crystal.
Identification IR should comply with the Reference Standard spectrum.
UV should comply with the Reference Standard spectrum.
An orange-red precipitate is performed.
IR complies with the Reference standard spectrum.
UV complies with the Reference standard spectrum.
An orange-red precipitate is performed.
Melting range 88 ~ 92 degree 89.8-90.2 degree
Loss on Drying Not more than 1.0% 0.22%
Readily carbonizable Substances The resolution has no more color than Matching Fluid A. Conform
Residue on ignition Not more than 0.1% 0.02%
Heavy metals Not more than 0.001% Conform
Chloride Conform Conform
Assay ( HPLC ) 98.0%-102.0% 99.96%
Ordinary Impurities ≤1% Conform
Reaction Conform Conform

 

 

Winstrol Stanozolol Pharmaceutical Grade Steroids For Anti Estrogen Muscle Growth

  • Winstrol Stanozolol Pharmaceutical Grade Steroids For Anti Estrogen Muscle Growth
Product Details:

Stanozolol Pharmaceutical Raw Materials Winstrol For Anti Estrogen Muscle Growth

 

 

Description

 

For anabolic steroid drugs, can promote protein synthesis, inhibit protein gluconeogenesis, reduce blood cholesterol and three acyl Gan oil, promote the deposition of calcium and phosphorus and reduce bone marrow suppression effect, can make the physical strength, appetite, weight gain. The prevention and treatment of hereditary angioneurotic edema; Severe trauma, chronic infection, malnutrition and other disease. Winstrol is a steroid compound that is available as both an oral and injectable. It is most often used as cutting agent because it doesn't produce huge weight gains and it also reverses some of the bloated look of testosterone and replaces it with a dry look.

 

The Stanozolol hormone is not well - suited for building mass; highly anabolic and very slightly androgenic this is a steroid far more apt for strength and cutting. Due to its ability to dramatically lower SHBG it could be used in a bulking cycle as a means to make other hormones more efficient, increase free testosterone and even solidify gains to a stronger degree but most will find other steroids to be far more beneficial in the long run; this truly is one of the few steroids we may aptly label a cutting steroid. For those who choose, Winstrol doses of 50mg per day might add a little to a bulking cycle at the tail-end providing benefits as discussed but generally speaking it is not our best option.

 

Without question Stanozolol is far more beneficial to a cutting cycle than it is a bulking cycle and many gym rats and competitive bodybuilders supplement with this steroid for just that purpose. Standard Winstrol doses will generally fall in the 50mg per day range for 6-8 weeks with some individuals choosing to go as high as 100mg per day for the entire duration of use. This is a bit of a high dose and can be fairly stressful to the liver as it is very hepatic and can further really curve your lipid profiles in a negative way. We can however make an exception with a higher Winstrol doses but only in short term fashion but it can be very useful. Winstrol doses of 100mg per day for the competitive bodybuilder the last 10-14 days before a competition can be very useful and as this is a very short period of time the liver and lipid issues are not as great of a concern. Many competitive bodybuilders will supplement with the Stanozolol hormone at 50mg per day for 6 weeks and then increase it to 100mg every day right before a show for the last two weeks to really add an additional level of hardness to their physique.

 

Pharmacology

 

As an AAS, stanozolol is an agonist of the androgen receptor ( AR ), similarly to androgens like testosterone and DHT. It is not a substrate for 5α - reductase as it is already 5α-reduced, and so is not potentiated in so-called " androgenic " tissues like the skin, hair follicles, and prostate gland. This results in a greater ratio of anabolic to androgenic activity compared to testosterone. In addition, due to its 5α - reduced nature, stanozolol is non - aromatizable, and hence has no propensity for producing estrogenic effects such as gynecomastia or fluid retention. Stanozolol also does not possess any progestogenic activity of significance. Because of the presence of its 17α - methyl group, the metabolism of stanozolol is sterically hindered, resulting in it being orally active, although also hepatotoxic.

 

Product Catalogs

 

Best Sellers Best Sellers
Testosterone Enanthate Tamoxifen Citrate
Testosterone propionate Clomifene Citrate
Testosterone Cypionate Toremifene Citrate
Testosterone Sustanon Anastrozole
Nandrolone Decanoate Letrazole
Nandrolone phenylpropionate Tadalafil ( Cialis )
Trenbolone Acetate Sildenafil ( Viagra )
Trenbolone Enanthate melanotan 2
Boldenone Undecylenate HGH 176-191
Methenolone Enanthate Benzocaine
Methenolone Acetate lidocaine
Oxymetholone lidocaine hcl
Oxandrolone procaine
Methandienone ( Dianabol ) procaine hcl
Stanozolol( winstrol )

4 - Chlorodehydromethyltestosterone

( Oral Turinabol )

1 - Test Cypionate / dihydroboldenone

4 - Chlorodehydromethyltestosterone

( Oral Turinabol )

Neuromodulators Progesterone Powder , Pharmaceutical Grade Steroids Progesterone Hormone

  • Neuromodulators Progesterone Powder , Pharmaceutical Grade Steroids Progesterone Hormone
Product Details:

Neuromodulators Progesterone Pharmaceutical Raw Materials for hormone replacement therapy Sex drive

 

 

Description

 

Progesterone is a hormone released by luteal cells in the ovaries which contains 21 Carbon Atoms. Progesterone is also a crucial metabolic intermediate in the production of other endogenous steroids. There are two crystal forms of progesterone, that are type-α and type-β, the two types have similar physiological activity. Type-α is precipitated from dilute ethanol as orthorhombic white prismatic crystal, while type-β is orthorhombic white needle crystal, they are both insoluble in water, but soluble in ethanol, ethyl ether, chloroform, acetone, dioxane and concentrated sulfuric acid.

 

 

Sexuality

Sex drive

 

Progesterone and its neurosteroid active metabolite allopregnanolone appear to be importantly involved in sex drive in females.

 

Homosexuality

 

Dr. Diana Fleischman, of the University of Portsmouth, and colleagues examined the relationship between progesterone and sexual attitudes. Their research was published in the Archives of Sexual Behavior. They found that women who have higher levels of progesterone are more likely to be open to the idea of engaging in sexual behaviour with other women. This pattern is particularly dramatic in men who have high levels of progesterone.

 

Nervous system

 

Progesterone, like pregnenolone and dehydroepiandrosterone ( DHEA ), belongs to an important group of endogenous steroids called neurosteroids. It can be metabolized within all parts of the central nervous system.

Neurosteroids are neuromodulators, and are neuroprotective, neurogenic, and regulate neurotransmission and myelination. The effects of progesterone as a neurosteroid are mediated predominantly through its interactions with non-nuclear PRs, namely the mPRs and PGRMC1, as well as certain other receptors, such as the σ1 and nACh receptors.

 

Aging

 

Since most progesterone in males is created during testicular production of testosterone, and most in females by the ovaries, the shutting down ( whether by natural or chemical means ), or removal, of those inevitably causes a considerable reduction in progesterone levels. Previous concentration upon the role of progestogens in female reproduction, when progesterone was simply considered a " female hormone ", obscured the significance of progesterone elsewhere in both sexes.

The tendency for progesterone to have a regulatory effect, the presence of progesterone receptors in many types of body tissue, and the pattern of deterioration ( or tumor formation ) in many of those increasing in later years when progesterone levels have dropped, is prompting widespread research into the potential value of maintaining progesterone levels in both males and females

Product Catalogs

 

Fermentation ( Starting Materials & Intermediates ) Chemical Synthesis ( Intermediates )
4-androstenedione ( 4 - AD ) Dehydroepiandrosterone ( DHEA )
1,4-androstadienedione ( ADD ) Epiandrosterone
9a - hydroxy - 4 - androstenedione ( 9- OH -4- AD ) Androstanolone
21 - hydroxy - 20 - methylpregn - 4 - ene - 3 - one ( Bisnoralcohol, BA ) Mestanolone
Sitolactone ( δ- Lactone ) 17a-hydroxyprogesterone
11 a, 17 a - dihydroxyprogesterone 19-nor-4-androstenedione
11 a - hydroxy Canrenone Methyldienedione ( Estra -4,9- diene -3,17-dione )
3b,7a,15a - trihydroxyandrost - 5 - ene - 17- one Tertraene Acetate ( 3TR )
  Tertraene 21 - Methyl ( 5ST )
Chemical Synthesis ( API ) Canrenone
Spironolactone Estrone
Stanozolol  
Progesterone Chemical Synthesis ( API )
Estradiol & esters Testosterone & esters
Estriol Nandrolone & esters
Altrenogest Boldenone & esters
  Trenbolone & esters
  Metenolone & esters

CAS 57-83-0 Pharmaceutical Grade Steroids Progesterone For Sexuality Skin Health

  • CAS 57-83-0 Pharmaceutical Grade Steroids Progesterone For Sexuality Skin Health
Product Details:

Female Progesterone Pharmaceutical Raw Materials Progesterone for Sexuality Skin health

 

 

Description

 

Progesterone ( abbreviated as P4 ), also known as pregn - 4 - ene - 3,20 - dione,is an endogenous steroid and progestogen sex hormone involved in the menstrual cycle, pregnancy, and embryogenesis of humans and other species. It belongs to a group of steroid hormones called the progestogens, and is the major progestogen in the body. Progesterone is also a crucial metabolic intermediate in the production of other endogenous steroids, including the sex hormones and the corticosteroids, and plays an important role in brain function as a neurosteroid.

 

Progesterone is a female Progesterone Hormones important for the regulation of ovulation and menstruation.

 

Women take progesterone by mouth for inducing menstrual periods who have not yet reached menopause but are not having periods due to a lack of progesterone in the body; And treating abnormal uterine bleeding associated with hormonal imbalance, and severe symptoms of premenstrual syndrome ( PMS ). Progesterone is also used to prevent overgrowth in the lining of the uterus in postmenopausal women who are receiving estrogen hormone replacement therapy. Progesterone is also used in combination with the hormone estrogen to " oppose estrogen " as part of hormone replacement therapy. If estrogen is given without progesterone, estrogen increases the risk of uterine cancer.

 

 

Reproductive system

 

Progesterone is sometimes called the " hormone of pregnancy ", and it has many roles relating to the development of the fetus:

  • Progesterone converts the endometrium to its secretory stage to prepare the uterus for implantation. At the same time progesterone affects the vaginal epithelium and cervical mucus, making it thick and impenetrable to sperm. Progesterone is anti-mitogenic in endometrial epithelial cells, and as such, mitigates the tropic effects of estrogen. If pregnancy does not occur, progesterone levels will decrease, leading, in the human, to menstruation. Normal menstrual bleeding is progesterone - withdrawal bleeding. If ovulation does not occur and the corpus luteum does not develop, levels of progesterone may be low, leading to anovulatory dysfunctional uterine bleeding.
  • During implantation and gestation, progesterone appears to decrease the maternal immune response to allow for the acceptance of the pregnancy.
  • Progesterone decreases contractility of the uterine smooth muscle.
  • In addition progesterone inhibits lactation during pregnancy. The fall in progesterone levels following delivery is one of the triggers for milk production.
  • A drop in progesterone levels is possibly one step that facilitates the onset of labor.

The fetus metabolizes placental progesterone in the production of adrenal steroids.

 

Product Catalogs

 

Fermentation ( Starting Materials & Intermediates ) Chemical Synthesis ( Intermediates )
4-androstenedione ( 4 - AD ) Dehydroepiandrosterone ( DHEA )
1,4-androstadienedione ( ADD ) Epiandrosterone
9a - hydroxy - 4 - androstenedione ( 9- OH -4- AD ) Androstanolone
21 - hydroxy - 20 - methylpregn - 4 - ene - 3 - one ( Bisnoralcohol, BA ) Mestanolone
Sitolactone ( δ- Lactone ) 17a-hydroxyprogesterone
11 a, 17 a - dihydroxyprogesterone 19-nor-4-androstenedione
11 a - hydroxy Canrenone Methyldienedione ( Estra -4,9- diene -3,17-dione )
3b,7a,15a - trihydroxyandrost - 5 - ene - 17- one Tertraene Acetate ( 3TR )
  Tertraene 21 - Methyl ( 5ST )
Chemical Synthesis ( API ) Canrenone
Spironolactone Estrone
Stanozolol  
Progesterone Chemical Synthesis ( API )
Estradiol & esters Testosterone & esters
Estriol Nandrolone & esters
Altrenogest Boldenone & esters
  Trenbolone & esters
  Metenolone & esters

Winstrol Stanozolol Pharmaceutical Grade Steroids C21H32N2O For Androgen Anabolic Steroid

  • Winstrol Stanozolol Pharmaceutical Grade Steroids C21H32N2O For Androgen Anabolic Steroid
Product Details:

Winstrol Stanozolol Pharmaceutical Raw Materials For Androgen Anabolic steroid C21H32N2O

 

 

Description

 

Winstrol is a popular name for the anabolic steroid stanozolol. This compound is a derivative of dihydrotestosterone, although its activity is much milder than this androgen in nature. It is technically classified as an anabolic steroid, shown to exhibit a slightly greater tendency for muscle growth than androgenic activity in early studies.

While dihydrotestosterone really only provides androgenic side effects when administered, stanozolol instead provides quality muscle growth. The anabolic properties of this substance are still mild in comparison to many stronger compounds, but it is still a ggod, reliable builder of muscle.
Its anabolic properties could even be comparable to Dianabol, but Winstrol does not have the same tendency for water retention. Stanozolol also contains the same c17 methylation we see with Dianabol, an alteration used so that oral administration is possible. To spite this design however, there are many injectable versions of this steroid produced.

Since stanozolol is not capable of converting into estrogen, an anti - estrogen is not necessary when using this steroid, gynecomastia is not a concern even among the most sensitive individuals.
Since estrogen is also the cause of water retention, instead of bulk look, Winstrol produces a lean, quality look with no fear of excess subcutaneous fluid retention. This makes it a great steroid to use during cutting cycles, when water and fat retention are a major concern. It is also very popular among athletes in combination strength / speed sports such as Track and Field.

 

Bodybuilding

 

Stanozolol is subject to non-medically supervised off - label use by some athletes for its anabolic properties frequently presenting with concomitant reduction of body fat. Stanozolol is a modified derivative of DHT and thus not aromatized to oestrogens via the aromatase class of enzymes ( see chemical structure to right ).

 

Bodybuilders frequently misuse the term " dry " in describing their joint pain while using stanozolol either orally or via IM injection of an aqueous suspension; a reference to their perceived reason for an increase in joint pain. Rather, stanozolol as a DHT derivative can selectively compete with progesterone and other natural and synthetic progestins ( nandrolone ) for progestin receptors; yielding a reduction in progesterone mediated anti - inflammatory processes and presenting patients with a perception of increased joint discomfort.

 

Stanozolol is used by athletes and bodybuilders to lose fat while retaining lean body mass. It is usually used in a " cutting or leaning out " cycle, to help preserve lean body mass while metabolizing adipose, although it has not been proven conclusively that it has any special fat-burning properties.

 

 

Product Catalogs

 

Fermentation ( Starting Materials & Intermediates ) Chemical Synthesis ( Intermediates )
4-androstenedione ( 4 - AD ) Dehydroepiandrosterone ( DHEA )
1,4-androstadienedione ( ADD ) Epiandrosterone
9a - hydroxy - 4 - androstenedione ( 9- OH -4- AD ) Androstanolone
21 - hydroxy - 20 - methylpregn - 4 - ene - 3 - one ( Bisnoralcohol, BA ) Mestanolone
Sitolactone ( δ- Lactone ) 17a-hydroxyprogesterone
11 a, 17 a - dihydroxyprogesterone 19-nor-4-androstenedione
11 a - hydroxy Canrenone Methyldienedione ( Estra -4,9- diene -3,17-dione )
3b,7a,15a - trihydroxyandrost - 5 - ene - 17- one Tertraene Acetate ( 3TR )
  Tertraene 21 - Methyl ( 5ST )
Chemical Synthesis ( API ) Canrenone
Spironolactone Estrone
Stanozolol  
Progesterone Chemical Synthesis ( API )
Estradiol & esters Testosterone & esters
Estriol Nandrolone & esters
Altrenogest Boldenone & esters
  Trenbolone & esters
  Metenolone & esters

Altrenogest Pharmaceutical Grade Steroids Veterinary Medicine For Controlling Mare Estrus

  • Altrenogest Pharmaceutical Grade Steroids Veterinary Medicine For Controlling Mare Estrus
  • Altrenogest Pharmaceutical Grade Steroids Veterinary Medicine For Controlling Mare Estrus
Product Details:

Altrenogest Pharmaceutical Raw Materials for Veterinary Medicine the control of estrus in mares

 

 

 

Description

 

Altrenogest also known as allyltrenbolone or allyltrienolone, as well as 17α - allyl - 19- nor - δ9,11-testosterone or 17α - allylestra -4,9,11- trien -17β - ol - 3- one, is a steroidal progestin of the 19-nortestosterone and allyltestosterone groups related to allylestrenol, norgestrienone, and trenbolone that is widely used in veterinary medicine to suppress or synchronize estrus in horses and pigs. It is available for veterinary use in both Europe and the United States and has been marketed as Regumate since the early 1980s.

 

Altrenogest is an estrane ( C18 ) steroid and 19 - nortestosterone derivative known chemically as 17α - allyl -19- nor - δ9,11- testosterone or 17α - allylestra -4,9,11- trien -17β - ol -3- one. It is one of only two marketed progestins that possesses a 17α - allyl group, the other being allylestrenol. Most other progestins possess a 17α - ethynyl group, while AAS, if they are 17α - substituted, are usually 17α - alkylated ( with a methyl or ethyl group ). Altrenogest is the 17α - allylated derivative of the AAS trenbolone (and hence can also be referred to as allyltrenbolone or allyltrienolone ), which itself is the 9,11- didehydro analogue of the AAS nandrolone ( 19 - nortestosterone ).

 

 

 

Usage

 

The pharmacodynamic activity of altrenogest has been demonstrated in a number of animal models. The most important effects are the progestomimetic and anti-gonadotrophic effects. Altrenogest also has weak oestrogenic, anabolic and androgenic effects, but has no corticoid or anti-inflammatory effects.

Altrenogest is indicated to suppress estrus in mares to allow a more predictable occurrence of estrus following withdrawal of the drug.

It is used clinically to assist mares to establish normal cycles during the transitional period from anestrus to the normal breeding season often in conjunction with an artificial photoperiod. It is more effective in assisting in pregnancy attainment later in the transition period. One group of authors ( Squires et al. 1983 ) suggest selecting mares with considerable follicular activity (mares with one or more follicles 20 mm or greater in size ) for treatment during the transitional phase. Mares that have been in estrus for 10 days or more and have active ovaries are also considered to be excellent candidates for progestin treatment.

Altrenogest is effective in normally cycling mares for minimizing the necessity for estrus detection, for the synchronization of estrus and permitting scheduled breeding.

Estrus will ensue 2-5 days after treatment is completed and most mares ovulate between 8-15 days after withdrawal. Altrenogest is also effective in suppressing estrus expression in show mares or mares to be raced. Although the drug is labeled as contraindicated during pregnancy, it has been demonstrated to maintain pregnancy in oophorectomized mares and may be of benefit in mares who abort due to sub-therapeutic progestin levels.

 

Product Catalogs

 

Fermentation ( Starting Materials & Intermediates ) Chemical Synthesis ( Intermediates )
4-androstenedione ( 4 - AD ) Dehydroepiandrosterone ( DHEA )
1,4-androstadienedione ( ADD ) Epiandrosterone
9a - hydroxy - 4 - androstenedione ( 9- OH -4- AD ) Androstanolone
21 - hydroxy - 20 - methylpregn - 4 - ene - 3 - one ( Bisnoralcohol, BA ) Mestanolone
Sitolactone ( δ- Lactone ) 17a-hydroxyprogesterone
11 a, 17 a - dihydroxyprogesterone 19-nor-4-androstenedione
11 a - hydroxy Canrenone Methyldienedione ( Estra -4,9- diene -3,17-dione )
3b,7a,15a - trihydroxyandrost - 5 - ene - 17- one Tertraene Acetate ( 3TR )
  Tertraene 21 - Methyl ( 5ST )
Chemical Synthesis ( API ) Canrenone
Spironolactone Estrone
Stanozolol  
Progesterone Chemical Synthesis ( API )
Estradiol & esters Testosterone & esters
Estriol Nandrolone & esters
Altrenogest Boldenone & esters
  Trenbolone & esters
  Metenolone & esters

Estriol Pharmaceutical Grade Steroids Against Breast Treating Multiple Sclerosis

  • Estriol Pharmaceutical Grade Steroids Against Breast Treating Multiple Sclerosis
Product Details:

Estriol Pharmaceutical Raw Materials Protects Against Breast Treating Multiple Sclerosis

 

 

Biological activity

 

Estriol is an estrogen, specifically an agonist of the estrogen receptors ERα and ERβ. It is a far less potent estrogen than is estradiol, and as such is a relatively weak estrogen. According to one in vitro study, the relative binding affinity ( RBA ) of estriol for the human ERα and ERβ was 11.3% and 17.6% of that estradiol, respectively, and the relative transactivational capacity of estrone at the ERα and ERβ was 10.6% and 16.6% of that of estradiol, respectively. According to another in vitro study however, the RBA of estriol for the ERα and ERβ were 14% and 21% of those of estradiol, respectively, suggesting that unlike estradiol and estrone, estriol may have preferential affinity for ERβ.

 

Although estriol is an efficacious agonist of the ERs, it is reported to have mixed agonist – antagonist ( partial agonist ) activity at the ER; on its own, it is weakly estrogenic, but in the presence estradiol, it is antiestrogenic. Relative to estradiol, the esstrogenic potency of estriol and estrone have been reported to be 80- and 12- fold lower than that of estradiol, respectively. It is notable that unlike estriol, estrone can be metabolized into estradiol, and most of its potency in vivo is in fact actually due to conversion into estradiol.

 

In addition to acting as an agonist of the nuclear ERs, estriol also acts as an antagonist of the GPER at high concentrations, a membrane estrogen receptor where, conversely, estradiol acts as an agonist. Estradiol increases breast cancer cell growth via activation of the GPER ( in addition to the ER ), and estriol has been found to inhibit estradiol - induced proliferation of triple-negative breast cancer cells through blockade of the GPER.

 

 

Distribution

 

Estriol is poorly bound to sex hormone - binding globulin ( SHBG ), with much lower binding affinity for this protein, relative to estradiol, and hence a greater fraction available for biological activity.

 

Product Catalogs

 

Estradiol Estrone
Estradiol valerate Estriol
Estradiol benzoate Nylestriol
Estradiol cypionate Diethylstilbestrol
Estradiol enantate HEXESTROL
Ethynyl estradiol Progesterone
Algestone acetophenide Medroxyprogesterone acetate
Ethisterone Norethindrone
19-Norethindrone acetate Mifepristone
Norethisterone Enanthate Methyldienedione
Ethynodiol diacetate Eplerenone
Pregnenolone acetate Levonorgestrel
Lynestrenol Allylestrenol
Chlormadinone acetate Dienogestrel
Cyproterone acetate Drospirenone
Megestrol acetate Pregnenolone
Melengestrol acetate Mometasone furoate
Betamethasone acetate Beclomethasone dipropionate
Betamethasone Dipropionate Betamethasone 17-valerate
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