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Steroid Hormones Hair Regrowth Powder 98319-26-7 , Finasteride For Male Sex Hormones

  • Steroid Hormones Hair Regrowth Powder 98319-26-7 , Finasteride For Male Sex Hormones
Product Details:

Steroid Hormones Medicine Raw Material Finasteride For Male Sex Hormones Propecia Hair Regrowth

 


Description

 

Finasteride, sold under the brand names Proscar and Propecia among others, is a medication used for the treatment of benign prostatic hyperplasia ( enlarged prostate ) and male pattern hair loss. It is a type II and type III 5α - reductase inhibitor; 5α - reductase, an enzyme, converts testosterone to dihydrotestosterone ( DHT ).

 

 

Medical uses

 

1. Prostate enlargement

 

Physicians sometimes use finasteride for the treatment of BPH, informally known as an enlarged prostate. Finasteride may improve the symptoms associated with BPH such as difficulty urinating, getting up during the night to urinate, hesitation at the start of urination, and decreased urinary flow. It provides less symptomatic relief than alpha -1 blockers such as tamsulosin and symptomatic relief is slower in onset ( six months or more of treatment with finasteride may be required to determine the therapeutic results of treatment ). Symptomatic benefits are mainly seen in those with prostate volume > 40 cm3. In long - term studies finasteride but not alpha-1 inhibitors reduce the risk of acute urinary retention ( −57% at 4 years ) and the need for surgery ( −54% at 4 years ). If the drug is discontinued, any therapeutic benefits reverse within about 6–8 months.

 

2. Pattern hair loss

 

Finasteride is sometimes used to treat pattern hair loss ( androgenetic alopecia ) in men only. Treatment slows further hair loss and provides about 30% improvement in hair loss after six months of treatment, with effectiveness usually only persisting as long as the drug is taken, although on occasion hair loss is slowed indefinitely following withdrawal. Finasteride has also been tested for pattern hair loss in women; the results were no better than placebo.

 

3. Excessive hair growth

 

Finasteride has been found to be effective in the treatment of hirsutism ( excessive facial and/or body hair growth ) in women. In a study of 89 women with hyperandrogenism due to persistent adrenarche syndrome, finasteride produced a 93% reduction in facial hirsutism and a 73% reduction bodily hirsutism after 2 years of treatment. Other studies using finasteride for hirsutism have also found it to be clearly effective.

 

4. Transgender women

 

Finasteride is sometimes used in hormone replacement therapy for transgender women due to its antiandrogen properties, in combination with a form of estrogen. However, little clinical research of finasteride use for this purpose has been conducted and evidence of efficacy is limited. Moreover, caution has been recommended when prescribing finasteride to transgender women, as finasteride may be associated with side effects such as depression, anxiety, and suicidal ideation, symptoms that are particularly prevalent in the transgender population and in others at high risk already.

Specification

 

Test Items Specification Test Results
Description White or off-white crystalline powder Off-white crystalline powder
Specific rotation -56°~-60° -58.2°
Identification IR Matches with working standard Complies
HPLC
Solubility Freely soluble in chloroform and in alcohol;
Very slightly soluble in water
Conform
Heavy metals ≤10ppm <10ppm
Water ≤0.3% 0.22%
Residue on ignition ≤0.1% 0.05%
Relative material Maximum impurities≤0.5% 0.36%
Total impurities≤1.0% 0.52%
Assay 98.5~101.0% 99.59%
Conclusion The specification conform with Enterprise standard

Finasteride Hair Regrowth Powder Medicine Raw Material 98319-26-7 For Prostatic Hyperplasia

  • Finasteride Hair Regrowth Powder Medicine Raw Material 98319-26-7 For Prostatic Hyperplasia
Product Details:

Finasteride Medicine Raw Material For prostatic hyperplasia male pattern hair loss 98319-26-7

 


Description

 

Finasteride is a 4 - azotypic compound, which is a specific inhibitor of intracellular enzyme - II type 5a - reductase in the process of testosterone metabolism. Benign prostatic hyperplasia or prostatic hypertrophy depends on the conversion of testosterone into dihydrotestosterone in the prostate.

 

This drug can effectively reduce blood and dihydrotestosterone in the prostate gland. The androgen receptor has no affinity for the androgen receptor. Finasteride belong to 5 alpha reductase inhibitors, the mechanism is through its hormone, the inhibition of testosterone into dihydrotestosterone (DHT), increase the shrinkage and improve symptoms of prostate and urinary flow rate, prevention of benign prostatic hyperplasia ( BPH ).

 

 

Function

 

This medication in a long - term efficacy and safety of ( PLESS ), in the study of symptoms of moderate to severe hyperplasia of prostate, 3016 prostate hyperplasia patients treated with this drug is 4 years relevant disposal ( surgical intervention ), urinary system such as transurethral resection of the prostate gland and other resection of the prostate, or need to insert the catheter acute urinary retention is evaluated.In this double - blind, randomized, placebo - controlled, multicenter study, treatment with this drug to the disposal of the overall risk of urinary system was reduced by 51%, with significant and sustained of prostate volume shrinking, and continuous maximum urinary flow rate increased and the symptoms improve.

 

 

Pharmacological effects

 

Finasteride is 4 - nitrogen compounds of steroid hormones, for specific Ⅱ type 5 alpha reductase inhibitors, inhibition of peripheral testosterone into dihydrotestosterone ( DHT ), reduce blood and prostate, skin, etc in DHT levels in the organization.The growth and development of the prostate and benign hyperplasia depends on DHT, finasteride by lowering blood and DHT levels in the prostate tissue and suppress hyperplasia of prostate and improve the related clinical symptoms of benign prostatic hyperplasia.

Indications

 

Used to treat prostatic hyperplasia.

 

 

Applicable people

 

BPH patients with enlarged prostate and lower urinary tract symptoms.

Patients with higher prostate volume ( 40ml ) and / or serum PSA levels ( PSA than 1.4ng/ml ) had better results

 

Specification

 

Test Items Specification Test Results
Description White or off-white crystalline powder Off-white crystalline powder
Specific rotation -56°~-60° -58.2°
Identification IR Matches with working standard Complies
HPLC
Solubility Freely soluble in chloroform and in alcohol;
Very slightly soluble in water
Conform
Heavy metals ≤10ppm <10ppm
Water ≤0.3% 0.22%
Residue on ignition ≤0.1% 0.05%
Relative material Maximum impurities≤0.5% 0.36%
Total impurities≤1.0% 0.52%
Assay 98.5~101.0% 99.59%
Conclusion The specification conform with Enterprise standard

 

98319-26-7 Hair Regrowth Powder Finasteride For Transgender Women Excessive Hair Growth

  • 98319-26-7 Hair Regrowth Powder Finasteride For Transgender Women Excessive Hair Growth
Product Details:

Finasteride Medicine Raw Material Finasteride For Transgender women Excessive hair growth

 


Description

 

Finasteride, also known as 17β-( N - tert - butylcarbamoyl )- 4- aza - 5α - androst - 1 - en - 3 - one, is a synthetic androstane steroid and 4 - azasteroid. It is an analogue of androgen steroid hormones like testosterone and DHT.

 

Finasteride is a lipophilic compound.

 

 

Society and culture

 

The Food and Drug Administration advises that donation of blood or plasma be deferred for at least one month after taking the last dose of finasteride.

Harold Bornstein, Donald Trump's personal physician, stated Trump was taking finasteride to promote hair growth.

 

Athletics

 

From 2005 to 2009, the World Anti - Doping Agency banned finasteride because it was discovered that the drug could be used to mask steroid abuse. It was removed from the list effective January 1, 2009, after improvements in testing methods made the ban unnecessary. Athletes who used finasteride and were banned from international competition include skeleton racer Zach Lund, bobsledder Sebastien Gattuso, footballer Romário and ice hockey goaltender José Théodore.

 

Brand names

Drug trade names include Propecia, marketed for male pattern baldness ( MPB ), and Proscar, for benign prostatic hyperplasia ( BPH ); both are products of Merck & Co. There is 1 mg of finasteride in Propecia and 5 mg in Proscar. Merck's patent on finasteride for the treatment of BPH expired on June 19, 2006. Merck was awarded a separate patent for the use of finasteride to treat MPB. This patent expired in November 2013.

 

Controversy

Men in the US and Canada concerned about persistent sexual side effects "coined the phrase 'post finasteride syndrome', which they say is characterized by sexual, neurological, hormonal and psychological side effects that can persist in men who have taken finasteride for hair loss or an enlarged prostate". In 2012, a health advocacy group called the Post - Finasteride Syndrome Foundation was formed with the primary goal of finding a cure for the reported syndrome and a secondary goal of raising awareness. According to the company's 1Q2016 financial filing, Merck is a defendant in 1,385 product liability lawsuits which have been filed by customers alleging they have experienced persistent sexual side effects following cessation of treatment with finasteride.

Usage

 

Sexual dysfunction

 

Whether finasteride causes long - term sexual dysfunction in some men after stopping drug treatment is unclear. There are case reports of persistent diminished libido or erectile dysfunction after stopping the drug and the FDA has updated the label to inform people of these reports. A 2010 review found moderate quality evidence that finasteride increased the risk of sexual dysfunction, but not that people stopped using it because of sexual side effects.

 

When finasteride was originally approved for hair loss in 1997, the FDA approval review reported that it appears well tolerated, with the most common side effects being related to sexual function. In many people these side effects resolve if the medication is stopped and occasionally resolve even if the medication is continued. They additionally state " the sexual functioning questionnaire seems to have given a sensitive reflection of the disturbance on sexual functioning ".

 

A meta - analysis and systematic review found that sexual dysfunction, including erectile dysfunction, loss of libido, and reduced ejaculate, may occur in 3.4 to 15.8% of men treated with finasteride or dutasteride. This is linked to lower quality of life and can cause stress in relationships. There is also an association with lowered sexual desire. It has been reported that in a subset of men, these adverse sexual side effects may persist even after discontinuation of finasteride or dutasteride.

Specification

 

Test Items Specification Test Results
Description White or off-white crystalline powder Off-white crystalline powder
Specific rotation -56°~-60° -58.2°
Identification IR Matches with working standard Complies
HPLC
Solubility Freely soluble in chloroform and in alcohol;
Very slightly soluble in water
Conform
Heavy metals ≤10ppm <10ppm
Water ≤0.3% 0.22%
Residue on ignition ≤0.1% 0.05%
Relative material Maximum impurities≤0.5% 0.36%
Total impurities≤1.0% 0.52%
Assay 98.5~101.0% 99.59%
Conclusion The specification conform with Enterprise standard

High Purity Propecia Hair Regrowth Powder , Oral Finasteride Proscar For Prostate Disease

  • High Purity Propecia Hair Regrowth Powder , Oral Finasteride Proscar For Prostate Disease
Product Details:

Oral Finasteride Proscar Pharmaceutical Raw Materials For Hairloss Treatment Prostate Disease

 

 

Description

 

Propecia ( finasteride ) is used to treat male pattern baldness ( androgenic alopecia ) in men. Oral use though will reduce DHT levels systemically, which may adversely affect training and sex drive.

It is also used in combination with doxazosin in the treatment of benign prostatic hyperplasia ( BPH ). ] Finasteride is an orally active testosterone Type II 5-alpha reductase inhibitor, inhibiting the enzyme that converts testosterone to dihydrotestosterone ( DHT ).

 

Topically ( on the scalp itself ) it is of some effect in minimizing further hair loss. In combination with Nizoral and spironolactone ( which smells awful, by the way ) it can actually reverse loss moderately.

For use in cycles with testosterone, I don't think it is bad at all. One simply doesn't want less DHT than normal. As the amount of testosterone in the system increases, the amount of finasteride needed to keep levels down to normal increases. I consider 5 mg/day reasonable at the gram per week level, and proportionally less at lower dosages of testosterone.

 

 

Applications

 

Propecia ( finasteride ) is used to treat male pattern baldness ( androgenic alopecia ) in men. Topically (on the scalp itself) it is of some effect in minimizing further hair loss. In combination with Nizoral and spironolactone ( which smells awful, by the way ) it can actually reverse loss moderately.

Used for the treatment of prostate disease first. Clinical studies suggest that, with finasteride 1 mg/day, continuous oral 3 months or slightly long can have hair growth, after continuous treatment 1 year hair growth rate to 48%, and can continue to fall off, taking the hair organization 2 years hair growth rate reached 66% ~ 83%.

 

Specification

 

Test Items Specification Test Results
Description White or off - white crystalline powder Off - white crystalline powder
Specific rotation -56°~-60° -58.2°
Identification IR Matches with working standard Complies
HPLC
Solubility Freely soluble in chloroform and in alcohol; Very slightly soluble in water Conform
Heavy metals ≤10ppm <10ppm
Water ≤0.3% 0.22%
Residue on ignition ≤0.1% 0.05%
Relative material Maximum impurities ≤0.5% 0.36%
Total impurities ≤1.0% 0.52%
Assay 98.5~101.0% 99.68%
Conclusion The specification conform with USP29

53-43-0 Hair Regrowth Powder Dhea Dehydroepiandrosterone Increasing Endogenous Production

  • 53-43-0 Hair Regrowth Powder Dhea Dehydroepiandrosterone Increasing Endogenous Production
Product Details:

Androgen Pharmaceutical Raw Materials Dehydroepiandrosterone Increasing endogenous production

 

 

Description

 

Dehydroepiandrosterone ( DHEA ), also known as androstenolone, is an endogenous steroid hormone. It is one of the most abundant circulating steroids in humans, in whom it is produced in the adrenal glands, the gonads, and the brain, where it functions as a metabolic intermediate in the biosynthesis of the androgen and estrogen sex steroids. However, DHEA also has a variety of potential biological effects in its own right, binding to an array of nuclear and cell surface receptors, and acting as a neurosteroid and neurotrophin.

 

 

 

Biological function

1. As an androgen

DHEA and other adrenal androgens such as androstenedione, although relatively weak androgens, are responsible for the androgenic effects of adrenarche, such as early pubic and axillary hair growth, adult - type body odor, increased oiliness of hair and skin, and mild acne. Women with complete androgen insensitivity syndrome ( CAIS ), who have a non-functional androgen receptor ( AR ) and are immune to the androgenic effects of DHEA and other androgens, have absent or only sparse/scanty pubic and axillary hair and body hair in general, demonstrating the role of DHEA, testosterone, and other androgens in body hair development at both adrenarche and pubarche.

2. As a neurosteroid

As a neurosteroid and neurotrophin, DHEA has important effects in the central nervous system.

 

 

Metabolism

 

DHEA is transformed into DHEA - S by sulfation at the C3β position via the sulfotransferase enzymes SULT2A1 and to a lesser extent SULT1E1. This occurs naturally in the adrenal cortex and during first - pass metabolism in the liver and intestines when exogenous DHEA is administered orally. Levels of DHEA - S in circulation are approximately 250 to 300 times those of DHEA. DHEA-S in turn can be converted back into DHEA in peripheral tissues via steroid sulfatase ( STS ).

 

The terminal half-life of DHEA is short at only 15 to 30 minutes. In contrast, the terminal half-life of DHEA - S is far longer, at 7 to 10 hours. As DHEA - S can be converted back into DHEA, it serves as a circulating reservoir for DHEA, thereby extending the duration of DHEA.

Metabolites of DHEA include DHEA-S, 7α-hydroxy - DHEA, 7β - hydroxy - DHEA, 7- keto - DHEA, 7α - hydroxyepiandrosterone, and 7β - hydroxyepiandrosterone, as well as androstenediol and androstenedione.

 

Product Catalogs

 

Fermentation ( Starting Materials & Intermediates ) Chemical Synthesis ( Intermediates )
4-androstenedione ( 4 - AD ) Dehydroepiandrosterone ( DHEA )
1,4-androstadienedione ( ADD ) Epiandrosterone
9a - hydroxy - 4 - androstenedione ( 9- OH -4- AD ) Androstanolone
21 - hydroxy - 20 - methylpregn - 4 - ene - 3 - one ( Bisnoralcohol, BA ) Mestanolone
Sitolactone ( δ- Lactone ) 17a-hydroxyprogesterone
11 a, 17 a - dihydroxyprogesterone 19-nor-4-androstenedione
11 a - hydroxy Canrenone Methyldienedione ( Estra -4,9- diene -3,17-dione )
3b,7a,15a - trihydroxyandrost - 5 - ene - 17- one Tertraene Acetate ( 3TR )
  Tertraene 21 - Methyl ( 5ST )
Chemical Synthesis ( API ) Canrenone
Spironolactone Estrone
Stanozolol  
Progesterone Chemical Synthesis ( API )
Estradiol & esters Testosterone & esters
Estriol Nandrolone & esters
Altrenogest Boldenone & esters
  Trenbolone & esters
  Metenolone & esters

 

2426-02-0 Hair Regrowth Powder 3,4,5,6,- Terahydrophthalic Anhydride TMMA

  • 2426-02-0 Hair Regrowth Powder 3,4,5,6,- Terahydrophthalic Anhydride TMMA
Product Details:

TMMA Medicine Raw Material for unsaturated polyester resins and hardener of epoxy resins 2426-02-0

 


Description

 

We have many chemists in the middle management with various organic, medicinal chemistry, OLED materials, Nono materials experience and expertise, Many of them have been trained overseas. With this team, we have the capability of supporting all kinds of chemistry projects.

 

We have rich experience in exporting to Europe and the United States and other countries for many years. Our freight forwarders have efficient customs clearance ability in countries such as Europe and the United States.When you order in our company, we will immediately arrange shipment and update tracking information for you by email.In addition,we can also arrange door to door service delivering to your office or factory directly by our forwarders.

 

 

Usage

 

This product is mainly used in insecticides, chrysanthemum lipid pesticide intermediates, unsaturated polyester resins, hardener of epoxy resins and plasticizers.

 

 

Specification

 

Appearance Yellow flaky solid
Purity ≥96.0%

Packing

 

25kg/bag,500kg/bag

 

 

Storage

 

This product shall be airtight, out of the sun, moisture-proof and away from het .The storage period is one year.

 

Product name
3,4,5,6,-Terahydrophthalic Anhydride (TMMA)
  CAS NO: 2426-02-0
  Molecular formula
Chemical formula: C8H8O3
Structural formula:
Molecular weight: 152.15
  Technical indicators
Yellow flaky solid,≧96.0%
  Use
This product is mainly used in insecticides, chrysanthemum lipid pesticide intermediates, unsaturated polyester resins, hardener of epoxy resins and plasticizers.
  Packing
25kg/bag
  Storage
This product shall be airtight, out of the sun, moisture-proof and away from heat. The storage period is one year.

Main Advantage

 

We can provide costomers with "one-stop"packaging service,from research,development,production,export and so on.
Powerful R&D strength let our technology in a leading level,forever,in turn,to provide customers with better service .
We have ISO&SGS certificate which let the customers more satisfied and rest assured.
More than 10 years of export experience,we can provide customers with more professional service.
Mix and different products in ONE PCL,increase the working efficiency for customers.
Headquartered in Shanghai, Shanghai is one of the world's largest port, convenient for the customes provide logistics services.

 

 

Contact Details
Shanghai Poochun Industry Co.,Ltd

Tel: 86-21-20935130

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